Inhibitory Effect of 2,5-Dimethylpyrazine on Oxytocic Agent -induced Uterine Hypercontraction of Normal or Pregnant Female Rats

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概要

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• Intraperitoneal administration of 2,5-dimethylpyrazine (2,5-DMP) was found to inhibit oxytocin- and prostaglandin F_<2α> -induced tetanic uterine contractions in normal or pregnant female rats. This suggests that 2,5-DMP may be used as a countercontraction agent or relaxant for preventing oxytocic agent-induced medical accident including uterine rupture or pressure death of the fetus due to uterine contractions.

• 公益社団法人日本薬学会の論文
• 1998-05-15

著者

• YAMADA Kenji

  Tokyo University of Science

• FUJIHARA Hisato

  Tokyo University of Pharmacy and Life Science, School of Pharmacy

• OHTA Akihiro

  Tokyo University of Pharmacy and Life Science, School of Pharmacy

• Yamada K

  Graduate School Of Pharmaceutical Sciences Kyushu University

• Ohta A

  Faculty Of Science Shinshu University

• Kobayashi Yoshiharu

  Tokyo University of Pharmacy and Life Science

• Ohta Akihiro

  Tokyo University Of Pharmacy And Life Science School Of Pharmacy

• Yamada Katsuya

  Graduate School Of Pharmaceutical Sciences Nagoya City University

• Ohta A

  Tokyo University Of Pharmacy And Life Science School Of Pharmacy

• Fujihara Hisato

  Tokyo University Of Pharmacy And Life Science School Of Pharmacy

• Yamada Kenji

  Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy

• Yamada Kenji

  Tokyo University Of Pharmacy And Life Science School Of Pharmacy

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