Effect of 2,5-Dimethylpyrazine on Uterine Contraction in Late Stage of Pregnant Female Rats(Pharmacology)
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概要
- 論文の詳細を見る
Effect of 2,5-dimethylpyrazine (2,5-DMP) on oxytocic agent-induced late pregnant uterine contraction in female rats was studied. Oxytocic agents induced-hypercontraction in the late phase of pregnant uterine movements were inhibited by administration of 2,5-DMP. The inhibition of uterine contraction was obtained more strengthening by presence of a low dose of ritodrine hydrochloride than 2,5-DMP alone. These results suggests that 2,5-DMP has an inhibitory action on uterine hypercontraction induced by oxytocic agent through the β_2-adrenoceptor in the pregnant uterus and supports the appllicability of relaxing drugs for oxytocic agent-induced accidents.
- 公益社団法人日本薬学会の論文
- 2003-11-01
著者
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Sano Motohiko
Department Of Pharmacy Services Saitama Medical Center Saitama Medical University:faculty Of Pharmac
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YAMADA Kenji
Tokyo University of Science
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Sano M
Department Of Pharmacy Services Saitama Medical Center Saitama Medical University:faculty Of Pharmac
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SANO Miwa
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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FUJIHARA Hisato
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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OHTA Akihiro
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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Yamada K
Graduate School Of Pharmaceutical Sciences Kyushu University
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Ohta A
Faculty Of Science Shinshu University
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Ohta Akihiro
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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Yamada Katsuya
Graduate School Of Pharmaceutical Sciences Nagoya City University
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Ohta A
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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Fujihara Hisato
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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Yamada Kenji
Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy
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Yamada Kenji
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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