Effect of 3,6-Dimethylpyrazine-2-thiol on Androstenedione-Induced Increase of Uterine Weight in Female Rats
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概要
- 論文の詳細を見る
3,6-Dimethylpyrazine-2-thiol administered at 10-70 mg/kg, p.o. was found to suppress androstenedione-in-duced increase of uterine weight in female rats. This action was weaker than that of aminoglutethimide (3-30 mg/kg, p.o.). After administration of androstenedione, increased plasma estradiol levels were reduced by 3,6-dimethylpyrazine-2-thiol. Moreover, in vitro, production of estradiol in the pregnant mare serum gonadotropin (PMSG)-treated ovary was inhibited by 3,6-dimethylpyrazine-2-thiol. These results suggest that 3,6-dimethylpyrazine-2-thiol has an inhibitory action on aromatase activity.
- 公益社団法人日本薬学会の論文
- 1999-12-15
著者
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YAMADA Kenji
Tokyo University of Science
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OHTA Akihiro
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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Ohta Akihiro
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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SUGAWARA Sohei
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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OHMORI Keiko
Tokyo University of Pharmacy and Life Science, School of Pharmacy
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Ohmori Keiko
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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Sugawara S
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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Yamada Kenji
Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy
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Yamada Kenji
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
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