Total Synthesis of (-)-Bulgecinine
スポンサーリンク
概要
- 論文の詳細を見る
A short synthetic route to (-)-bulgecinine (1), the amino acid moiety of bulgecins, was established by using 1,3-dipolar cycloaddition of N-benzyl-α-methoxycarbonylmethanimine N-oxide (6) to a chiral allylic alcohol (5) with moderate threo selectivity as the key reaction.
- 公益社団法人日本薬学会の論文
- 1997-06-15
著者
-
前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
-
Aoyagi Y
Niigata Univ. School Of Medicine Niigata Jpn
-
Aoyagi Yutaka
Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy
-
Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
-
Aoyagi Yutaka
School of Pharmacy, Tokyo University of Pharmacy & Life Science
-
OHTA Akihiro
Tokyo University of Pharmacy and Life Science, School of Pharmacy
-
Ohta A
Faculty Of Science Shinshu University
-
MAEDA Mikiko
School of Pharmacy, Tokyo University of Pharmacy and Life Science
-
OKAZAKI Fumiaki
School of Pharmacy, Tokyo University of Pharmacy and Life Science
-
MURAYAMA Mayumi
School of Pharmacy, Tokyo University of Pharmacy and Life Science
-
TACHIBANA Yohko
School of Pharmacy, Tokyo University of Pharmacy and Life Science
-
OHTA AKihiro
School of Pharmacy, Tokyo University of Pharmacy and Life Science
-
Aoyagi Y
Tokyo University Of Pharmacy And Life Sciences School Of Pharmacy
-
Murayama M
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
-
Okazaki F
School Of Pharmacy Tokyo University Of Pharmacy And Life Science
-
Tachibana Y
Nisshin Flour Milling Co. Ltd. Saitama Jpn
-
Ohta A
Tokyo University Of Pharmacy And Life Science School Of Pharmacy
-
Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
関連論文
- Amino Acids and Peptides. XXVI. Laminin-Related Peptide Poly (Ethylene Glycol) Hybrids and Their Inhibitory Effect on Experimental Metastasis
- Cell-Penetrating Peptides as Adenovirus Vector Carrier
- Amino Acids and Peptides. XXIV. Preparation and Antinociceptive Effect of [D-Ala^2,(N-Me)Phe^4]Enkephalin Analog-Poly(Ethylene Glycol)Hybrids
- Amino Acids and Peptides. XXIII. Leu-Enkephalin Analogs Containing a Fluorinated Amino Acid at Position 2,4 or 5
- Human Chorionic Gonadotropin. VII. Preparation and Immunocharacteristics of Carboxyl-terminal Peptides of the β-Subunit of Human Chorionic Gonadotropin
- Human Chorionic Gonadotropin. II. Synthesis of a Hexadecapeptide corresponding to the C-Terminal Sequence 132-147 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
- Preparation of New Nitrogen-Bridged Heterocycles. 60. Syntheses and Conformational Analyses of Bis(indolizin-1-yl) Disulfides
- 生理活性ペプチドの高分子ハイブリッド化 DDS - ポリスチレンマレイン酸によるラミニン関連細胞接着ペプチドのバイオコンジュゲーションとその癌転移抑制効果 -
- Amino Acids and Peptides. XXII. Preparation and Antinociceptive Effect of [D-Ala^2] Leu-Enkephalin-Poly (Ethylene Glycol) Hybrid
- Amino Acids and Peptides. XIX. Preparation of Enkephalin-Poly(ethylene glycol) Hybrid and Evaluation of Its Analgesic Activity
- Synthesis of a Tetradecapeptide corresponding to Sequence 90-103 of Bovine Adrenodoxin
- Amino Acids and Peptides. I. Synthesis of a Model Peptide related to Iron-Sulfur Protein
- P1-582 模擬患者を活用した初年次教育の実践とその教育的成果(一般演題 ポスター発表,薬学教育(その他),臨床から学び臨床へと還元する医療薬学)
- Preparation and Biological Activities of a Bivalent Poly(Ethylene Glycol) Hybrid Containing an Active Site and Its Synergistic Site of Fibronectin
- Amino Acids and Peptides. X. : Leu-Enkephalin Analogues Containing a Fluorinated Aromatic Amino Acid
- Amino Acids and Peptides. IX. : Synthetic Studies on Leu-Enkephalin Analogues Containing a Ureylene Bond
- Amino Acids and Peptides. VII. : Preparation and Application of a Water-Soluble Active Ester, p-Trimethylammoniophenyl Ester
- Amino Acids and Peptides. IV. Synthesis and Analgesic Effects of Tyr-Containing Dipeptide Phenethylamides
- Preparation of New Nitrogen-Bridged Heterocycles. 56. Syntheses and Reactions of 1-[2,2-Bis(alkylthio)-1-(ethoxycarbonylacetyl)vinyl]pyridinium Salts
- Cytotoxic Bisnor- and Norditerpene Dilactones Having 7α,8α-Epoxy-9,11-enolide Substructure from Podocarpus macrophyllus D. DON
- Antibacterial Novel Phenolic Diterpenes from Podocarpus macrophyllus D. DON
- Studies on Heterobifunctional Cross-Linking Reagents, 6-Maleimidohexanoic Acid Active Esters
- "Solid Phase Synthesis in Water" Using Fmoc-Amino Acid Nanoparticles
- Amino Acids and Peptides.XXXVIII.Facile Synthesis of Laminin-Related Peptide-Poly(Ethylene Glycol)Hybrids by the Solid Phase Method
- Synthesis of Peptide Mimetics That Related to Tethered Thrombin Receptor and Their Agonist/Antagonist Activities on Platelet Aggregation
- Evaluation of a New N-Protecting Group, 2-(4-Sulfophenylsulfonyl)ethoxycarbonyl Group, for Solid Phase Peptide Synthesis in Water
- Peptide Synthesis in Water IV. Preparation of N-Ethanesulfonylethoxycarbonyl (Esc) Amino Acids and Their Application to Solid Phase Peptide Synthesis
- Solid Phase Synthesis in Water : Application of the Ethanesulfonylethoxycaronyl (Esc) Group
- Improved Preparation of an Amino Acid Type Poly(Ethylene Glycol) Derivative
- A New N-Protecting Group, 2-[Phenyl(methyl)sulfonio]ethyloxycarbonyl Tetrafluoroborate, and Its Application to Solid Phase Peptide Synthesis in Water
- Acylation of Hydrazides with Acetic Acid and Formic Acid
- A Bivalent Poly (ethylene glycol) Hybrid Containing an Active Site (RGD) and a Synergistic Site of Fibronectin
- Amino Acids and Peptides. XXXV. Facile Preparation of p-Nitroanilide Analogs by the Solid-Phase Method
- A Facile Solid-Phase Synthesis of Peptide ρ-Nitroanilide Analogs
- Amino Acids and Peptides. VIII. : A Water-Soluble Active Ester, Phenolsulfonic Acid Derivative(Organic,Chemical)
- Amino Acids and Peptides. XX. Preparation of β-Cyclododecyl Aspartate and Its Application to Synthesis of Fibronectin- and Laminin-Related Peptides
- Preparation of Laminin γ1 Chain Related Peptide Poly (Ethylene Glycol) Hybrid
- Amino Acids and Peptides. XXXI. Preparation of Analogs of the Laminin-Related Peptide YIGSR and Their Inhibitory Effect on Experimental Metastasis
- Amino Acids and Peptides. XXX. Preparation of Arg-Gly-Asp (RGD) Hybrids with Poly(Ethylene Glycol) Analogs and Their Antimetastatic Effect
- Amino Acids and Peptides. XXIX. Synthesis and Antimetastatic Effects of Peptides and Peptide-Poly(Ethylene Glycol) Hybrids Related to the Core Sequence of the Type III Connecting Segment Domain of Fibronectin
- Effect of 2,5-Dimethylpyrazine on Uterine Contraction in Late Stage of Pregnant Female Rats(Pharmacology)
- Amino Acids and Peptides. XXVII. Solid Phase Synthesis of Fibrinogen-Related Peptides with Disulfide Bond Formed on Solid Support
- Preparation of Laminin-related Peptide Analogs and Their Inhibitory Effect on Experimental Metastasis in Mice
- Apoptosis-inducing Activity of High Molecular Weight Fractions of Tea Extracts
- The Carboxyl Terminal Sequence of Rat Transporter Associated with Antigen Processing (TAP)-Like (ABCB9) is Heterogeneous due to Splicing of Its mRNA(Biochemistry/Molecular Biology)
- Effect of Alkylpyrazine Derivatives on the Duration of Pentobarbital-Induced Sleep, Picrotoxicin-Induced Convulsion and γ-Aminobutyric Acid(GABA)Levels in the Mouse Brain
- Inhibitory Effect of 2,5-Dimethylpyrazine on Oxytocic Agent -induced Uterine Hypercontraction of Normal or Pregnant Female Rats
- Anti-Platelet Aggregation Activity of Some Pyrazines
- Total Synthesis of (-)-Bulgecinine
- Samarium(II) Iodide-Mediated Intermolecular Coupling Reactions of N, N-Dibenzylenamides with Carbonyl Compounds and Transformation of the Product, N, N-Dibenzyl-γ-hydroxyamide to δ-Aminoalcohol
- Apoptosis Induction by Lectin Isolated from the Mushroom Boletopsis leucomelas in U937 Cells(Biochemistry & Molecular Biology)
- A Fibronectin-binding Protein from Rice Bran with Cell Adhesion Activity for Animal Tumor Cells
- Bilirubin Binding Activity of Cytokeratin 18 Isolated from the Porcine Liver
- Isolation of a 41-kDa Protein with Cell Adhesion Activity for Animal Tumor Cells from the Mushroom Hypsizigus marmoreus by Affinity Chromatography with Type IV Collagen Immobilized on Agarose
- Effect of 3,6-Dimethylpyrazine-2-thiol on Androstenedione-Induced Increase of Uterine Weight in Female Rats
- Effects of 3,6-Dimethylpyrazine-2-thiol on Reproductive and Accessory Reproductive Organs in Male Rats
- Apoptosis-inducing Activity of Polyphenol Compounds Derived from Tea Catechins in Human Histiolytic Lymphoma U937 Cells
- Amino Acids and Peptides. V. Synthesis of Amino Acid Derivatives Containing a Sulfonamide Bond
- Membrane Localization of Transporter Associated with Antigen Processing (TAP)-Like (ABCB9) Visualized in Vivo with a Fluorescence Protein-Fusion Technique(Biochemistry/Molecular Biology)
- A Half-Type ABC TRansporter TAPL Is Highly Conserved between Rodent and Man, and the Human Gene Is Not Responsive to Interferon-γ in Contrast to TAP1 and TAP2^1
- Structures of P-type Transporting ATPases and Chromosomal Locations of Their Genes
- Preparation of A Fibronectin-related Poly(Ethylene Glycol) Hybrid and Its Inhibitory Effect on Experimental Metastasis in Mice
- Amino Acids and Peptides. III. Synthesis of Model Peptides Related to Cytochrome P-450
- The Opioid Activity and Receptor Selectivity of Fluorinated Leu^5 Enkephalin Analogues in Vitro and in Vivo
- Selectivity for Opioid Receptor Subtypes of Enkephalin Analogues in Isolated Smooth Muscle and in the Analgesic Effect in Mice
- INVOLVEMENT OF DIFFERENT RECEPTOR SUBTYPES FOR THE PRODUCTION OF IN VITRO AND IN VIVO EFFECTS IN A SERIES OF SYNTHETIC ENKEPHALIN ANALOGUES
- Semisynthesis of Isetexane Diterpenoid Analogues and Their Cytotoxic Activity
- プリオンタンパク質の銅結合部位
- A Convenient Method for Retro-Cycloadditon of Adducts from Steroidal 5,7-Dienes and 4-Phenyl-1,2,4-triazolidine-3,5-dione and Application to the Syntheses of Biosynthetic Intermediates of Ergosterol