Amino Acids and Peptides. X. : Leu-Enkephalin Analogues Containing a Fluorinated Aromatic Amino Acid
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概要
- 論文の詳細を見る
Leu-enkephalin analogues containing a fluorinated derivative of Tyr^1 or Phe^4 were synthesized by the solid-phase method and their biological activities were studied. Fluorination of the p-position of Phe^4 resulted in a marked potentiation of the inhibitory effect on electrically induced contractions of guinea-pig ileum (GPI) and mouse vas deferens (MVD). On the other hand, substitution of fluorine for the hydroxyl group of Tyr^1 or introduction of a trifluoromethyl group at the p-position of Phe^4 markedly reduced the inhibitory effect in both preparations. Fluorination of other positions of Tyr^1 and Phe^4 did not cause substantial changes in the activities as compared with Leu-enkephalin.
- 社団法人日本薬学会の論文
- 1989-03-25
著者
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川崎 紘一
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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前田 光子
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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金戸 洋
長崎大学薬学部薬物学教室
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金戸 洋
Department of Pharmacology, Faculty of Pharmaceutical Sciences Nagasaki University
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前田 光子
Life Science Center Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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Maeda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University:faculty Of Pharmac
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渡辺 穣
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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渡辺 穣
神戸学院大学 薬
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渡辺 穰
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Nagasaki University
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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川崎 紘一
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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Maeda Masatomo
Laboratory Of Biochemistry And Molecular Biology Graduate School Of Pharmaceutical Sciences Osaka Un
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