Facile Conversions of Carboxylic Acids into Amides, Esters, and Thioesters Using 1,1'-Oxalyldiimidazole and 1,1'-Oxalyldi(1,2,4-triazole)(Organic,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
Aliphatic, aromatic, and heteroaromatic carboxylic acids react with 1,1'-oxalyldiimidazole (1) or 1,1'-oxalyldi(1,2,4-triazole) (2) in acetonitrile for 40min at 40℃ to give the corresponding 1-acylazole intermediates (11), which promptly undergo aminolysis and alcoholysis to form amides (13) including dipeptides (14), esters (16), and thioesters (19). These findings show that both 1 and 2 can be utilized as condensing reagents for the synthesis of carboxylic acid derivatives.
- 社団法人日本薬学会の論文
- 1987-10-25
著者
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佐々木 秀明
Faculty of Pharmaceutical Sciences
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北川 徳治郎
Faculty of Pharmaceutical Sciences
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川崎 紘一
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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佐々木 秀明
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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北川 徳治郎
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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黒田 浩子
Faculty of Pharmaceutical Sciences, Kobe Gakuin University
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Kawasaki Keiko
Biological Science Laboratories Kao Corporation
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黒田 浩子
Faculty Of Pharmaceutical Sciences Kobe Gakuin University
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川崎 紘一
Faculty Of Pharmaceutical Sciences & Cooperative Research Center Of Life Sciences Kobe Gakuin Un
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