SYNTHESIS OF A NOVEL BIS(2,4'-BITHIAZOLE) DERIVATIVE AS A Co(II)-ACTIVATED DNA CLEAVING AGENT
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概要
- 論文の詳細を見る
A novel DNA cleaving agent, N, N'-bis{2-[4-(3-aminopropylcarbamoyl)-2,4'-bithiazol-2'-yl]ethyl}ethylenediamine (1), was synthesized. At 25μM concentration, a significant cleaving activity of 1 for plasmid DNA was observed only in the presence of Co(II). Scavengers of active oxygen species could not inhibit the DNA cleavage by 1.
- 社団法人日本薬学会の論文
- 1994-08-15
著者
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佐々木 秀明
Faculty of Pharmaceutical Sciences
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佐々木 秀明
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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