Synthesis of Furan Derivatives. LXXXVIII. Reactivity of Tosylmethyl Isocyanide towards Azole Carbaldehydes

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概要

• 論文の詳細を見る

• Tosylmethyl isocyanide (4) reacted readily with azole carbaldehydes, i.e., indole-2-carbaldehyde (8a), pyrazole-3 (5)-carbaldehyde (8b), 3 (5)-methylpyrazole-5 (3)-carbaldehyde (8c), 3 (5)-(2-furyl) pyrazole-5 (3)-carbaldehyde (8d), 1,2,4-triazole-3 (5)-carbaldehyde (8e), and tetrazole-5-carbaldehyde (8f), in the presence of an equimolar amount of potassium carbonate in refluxing methanol to yield the corresponding 5-substituted oxazoles (10 and 15b-f) as the final products. In the case of the reaction of 4 with imidazole-2-carbaldehyde (8g), however, N-(1-tosyl-1-alkenyl) formamide of type 18g, 1-amino-1-tosyl-2-alkene of type 19g, and 3-tosylimidazo [1,2-c] pyrimidine (22g) were obtained, depending on the reaction conditions.

• 社団法人日本薬学会の論文
• 1982-11-25

著者

• 佐々木 秀明

  Faculty of Pharmaceutical Sciences

• 北川 徳治郎

  Faculty of Pharmaceutical Sciences

• 佐々木 秀明

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 北川 徳治郎

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• Leusen Albert

  Department Of Organic Chemistry Groningen University

• 西海枝 東雄

  Faculty of Pharmaceutical Sciences, Kobe Gakuin University

• 西海枝 東雄

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

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