Amino Acids and Peptides. XIII. : Synthesis of a Nonacosapeptide Corresponding to the N-Terminal Sequence 1-29 (β-Fragment) of Human Liver Metallothionein II (hMT II) and Its Heavy Metal-Binding Properties

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概要

• 論文の詳細を見る

• A nonacosapeptide corresponding to the N-terminal sequence 1-29 (β-fragment) of human liver metallothionein II (hMT II) was synthesized by the azide coupling of five peptide fragments [1,2,4,6 and 8], followed by HF deprotection and its heavy metal-binding properties were examined. It was revealed that the Cd-binding ability of the synthetic β-fragment as well as synthetic α-fragment corresponding to the C-terminal sequence 30-61 of hMT II was stronger than that of native rat thionein. Moreover, it was found that both the α-and β-fragments bound preferentially to Cu ions rather than Cd ions.

• 社団法人日本薬学会の論文
• 1986-03-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 閔 庚善

  Faculty of Nutrition, Kobe-Gakuin University

• 小野坂 敏見

  Faculty of Nutrition, Kobe-Gakuin University

• 田中 慶一

  Faculty of Nutrition , Kobe-Gakuin University

• 小野坂 敏見

  神戸学院大学栄養学部

• 閔 庚善

  神戸学院大学栄養学部

• 津田 裕子

  Faculty of Pharmaceutical Sciences

• 井口 伸

  Faculty of Pharmaceutical Sciences

• 大田 憲哉

  Faculty of Pharmaceutical Sciences

• 佐々木 秀明

  Faculty of Pharmaceutical Sciences

• 北川 徳治郎

  Faculty of Pharmaceutical Sciences

• 柳生 正見

  Faculty of Pharmaceutical Sciences

• 大田 憲哉

  Hitachi Chemical Co. Ltd. Ibaraki Research Laboratory

• 津田 裕子

  神戸学院大学薬学部薬品化学

• 佐々木 秀明

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 北川 徳治郎

  Faculty Of Pharmaceutical Sciences Kobe Gakuin University

• 井口 伸

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 柳生 正見

  Faculty Of Pharmaceutical Sciences:kobe-gakuin University

関連論文

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