Amino Acids and Peptides. XXXIX. Synthesis of iNoc-Gln-Val-Val-Ala-Ala-pNA and Its Action on Thiol Proteinases

スポンサーリンク

概要

• 論文の詳細を見る

• Based on the results of X-ray analysis of the complex between Suc-Gln-Val-Val-Ala-Ala-pNA, a fairly potent thiol proteinase inhibitor, and papain, iNoc-Gln-Val-Val-Ala-Ala-pNA was designed and prepared and its inhibitory activity against thiol proteinases was examined. iNoc-Gln-Val-Val-Ala-Ala-pNA inhibited cathepsin L fairly specifically, although its potency is not high.

• 社団法人日本薬学会の論文
• 1995-01-15

著者

• 松本 仁

  徳島文理大学

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 津田 裕子

  Faculty of Pharmaceutical Sciences

• 掛川 寿夫

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 佐藤 利夫

  徳島文理大学薬学部

• 平野 健一

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 佐藤 利夫

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 岡本 博

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• 松本 仁

  Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• 掛川 寿夫

  香川大学工学部

• 津田 裕子

  神戸学院大学薬学部薬品化学

• 牟 宇

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• 岡本 美子

  Daiichi College of Pharmaceutical Sciences

• 岡田 芳男

  神戸学院大学 薬学部

• 松本 仁

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Sato T

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 牟 宇

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• Mu Yu

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• Kakegawa Hisao

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• 松本 仁

  徳島文理大 薬

• 佐藤 利夫

  Faculty Of Pharmaceutical Sciences Tokushima Bunri University

• Matsumoto H

  Yamanouchi Pharmaceutical Co. Ltd. Ibaraki Jpn

• Okamoto Hiroshi

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

関連論文

• Amino Acids and Peptides. XXXV. Synthesis of Mouse Metallothionein I. (2). Synthesis of a Nonacosapeptide Corresponding to N-Terminal Sequence 1-29 (β-Fragment) of Mouse Metallothionein I and Related Peptides and Examination of Their Heavy Metal-Binding P
• Amino Acids and Peptides. XXXIV. Synthesis of Mouse Metallothionein I. (1). Synthesis of Dotriacontapeptide Corresponding to C-Terminal Sequence 30-61 (α-Fragment) of Mouse Metallothionein I and Related Peptides and Examination of Their Heavy Metal-Bindin
• Amino Acids and Peptides. XXVII. : Synthesis of Phytochelatin-Related Peptides and Examination of Their Heavy Metal-Binding Properties
• Amino Acids and Peptides. XXVI. Synthesis of Agaricus bisporus Metallothionein and Related Peptides and Examination of Their Heavy Metal-Binding Properties
• Amino Acids and Peptides. XXIV. : Synthesis of Neurospora crassa Metallothionein and Related Cysteine-Containing Peptides and Examination of Their Heavy Metal-Binding Properties
• Amino Acids and Peptides. XIII. : Synthesis of a Nonacosapeptide Corresponding to the N-Terminal Sequence 1-29 (β-Fragment) of Human Liver Metallothionein II (hMT II) and Its Heavy Metal-Binding Properties
• Amino Acids and Peptides. XXI. : Synthesis of N-Terminal Heptapeptide of Mammalian Metallothionein (MT) and Evaluation of Its Immunoreactivity
• Amino Acids and Peptides. XXXVII. Synthesis of Stereoisomeric Nonapeptides Corresponding to Sequence 41-49 of Eglin c and Examination of Their Inhibitory Activity against Human Leukocyte Cathepsin G and α-Chymotrypsin
• The Inhibitory Effect of Sulfated Schizophyllans and Related Oligosaccharides on Coagulation and Fibrinolysis
• Application of Poly-L-lysine to Purification of Leukocyte Cathepsin G by Affinity Chromatography
• Amino Acids and Peptide. XXX. Synthesis of Eglin c (41-49) and Eglin c (60-63) and Examination of Their Inhibitory Activity towards Human Leukocyte Elastase, Cathepsin G, Porcine Pancreatic Elastase and α-Chymotrypsin
• Amino Acids and Peptides. XXIX. Synthesis of Peptide Fragments Related to Active Center of Eglin c and Studies on the Relationship between Their Structure and Their Inhibitory Activity against Cathepsin G and α-Chymotrypsin
• SYNTHESIS OF A HEPTACONTAPEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF EGLIN C
• Amino Acids and Peptides. XXVIII. : Synthesis of Peptide Fragments Related to Eglin c and Studies on the Relationship between Their Structure and Effects on Human Leukocyte Elastase, Cathepsin G and α-Chymotrypsin
• Amino Acids and Peptides. XXII. : Synthesis of Substrates and Inhibitors of Human Leukocyte Cathepsin G
• Synthesis of Tripeptide Amide Derivatives and Examination of Their Inhibitory Effect on Human Leukocyte Elastase (HLE)
• Inhibition of α-Chymotrypsin by Suc-L-Tyr-D-Leu-D-Phe-pNA, a Stereoisomer of a Specific Substrate
• Synthesis of Chromogenic Substrates Specific for Human Spleen Fibrinolytic Proteinase (SFP) and Human Leukocyte Elastase (LE)
• CONVENIENT PURIFICATION OF HUMAN SPLEEN FIBRINOLYTIC PROTEINASE (SFP) AND HUMAN LEUCOCYTE ELASTASE BY AFFINITY CHROMATOGRAPHY
• Stereoisomeric Alanine Peptides as Substrates for Human Spleen Fibrinolytic Proteinase (SFP)
• Synthesis of Stereoisomeric Suc-Tyr-Leu-Val-pNA and Their Properties as Substrate and Inhibitor for Human Spleen Fibrinolytic Proteinase (SFP)
• Human Chorionic Gonadotropin. VII. Preparation and Immunocharacteristics of Carboxyl-terminal Peptides of the β-Subunit of Human Chorionic Gonadotropin
• Human Chorionic Gonadotropin. III. Synthesis of a Dotriacontapeptide corresponding to the C-Terminal Sequence 116-147 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
• Human Chorionic Gonadotropin. II. Synthesis of a Hexadecapeptide corresponding to the C-Terminal Sequence 132-147 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
• Synthesis of C-Terminal Peptides of the β-Subunit of Human Chorionic Gonadotropin (hCG)
• Amino Acids and Peptides. XII. Synthesis of C-Terminal Decapeptide of Bovine Pancreatic Ribonuclease A (RNase A) and Its Analogs and Determination of Their Ability to Reactivate Des (121-124) RNase A
• 土壌の裁判化学的研究(第1報)土壌の熱分解生成物を指標とする地域特定について
• Forensic Chemical Study on Human Hair. III. Identification of Oxidative Dyes and Presumption of the Brands from Remaining Components on Human Hair
• Forensic Chemical Study on Human Hair. II. Identification of Brand of Women's Hair Care Products by Remaining Components on Human Hair
• 毛髪の裁判化学的研究(第1報)毛髪付着残留成分による頭髪用化粧品類の銘柄識別について(その1)
• Amino Acids and Peptides. XXXIX. Synthesis of iNoc-Gln-Val-Val-Ala-Ala-pNA and Its Action on Thiol Proteinases
• INHIBITORY EFFECTS OF (4-ALKOXY-2,3,6-TRIMETHYLPHENYL) GLYCOPYRANOSIDES ON HISTAMINE RELEASE INDUCED BY ANTIGEN-ANTIBODY REACTION
• Synthesis and Anti Lipid-Peroxidation Activity of Hydroquinone Monoalkyl Ethers
• Synthesis of 4-Alkoxyaryl β-D-Glucopyranosides and Their Inhibitory Effects on Histamine Release from Rat Peritoneal Mast Cells Induced by Concanavalin A
• Protective Effects of Hydroxychalcones on Free Radical-Induced Cell Damage
• Anti-allergy Actions of Alkylphenyl α-D-Mannopyranosides
• Influences of Alkylphenyl α-D-Mannopyranosides on Histamine Release from Rat Peritoneal Mast Cells Induced by Concanavalin A
• Syntheses and Inhibitory Effects on Gastric Lesions of 4-Guanidinomethylbenzoic Acid Arylamides
• Pharmacological and Pharmaceutical Properties of Freeze-Dried Formulations of Egg Albumin, Indomethacin, Olive Oil, or Fatty Acids
• Inflammatory Activity of Polymeric Photoproducts of Chlorpromazine
• Syntheses and Inhibitory Effects on Gastric Lesions of trans-Guanidinomethylcyclohexane Carboxylic Acid Arylamides
• Inhibitory Effects of Some Natural Products on the Activation of Hyaluronidase and Their Antiallergic Actions
• コラゲナーゼ阻害剤に関する研究(第4報)黄連の細菌性コラゲナーゼ阻害活性成分の検索
• 3-O-Alkuylascorbic Acids as Free Radical Quenchers. II. Inhibitory Effects on Some Lipid Peroxidation Models
• コラゲナーゼ阻害剤に関する研究(第3報)アントラサイクリンの細菌性コラゲナーゼ阻害作用
• Inhibitory Effects of Tannins on Hyaluronidase Activation and on the Degranulation from Rat Mesentery Mast Cells
• Hyaluronidase-Inhibitory and Anti-allergic Activities of the Photo-Irradiated Products of Tranilast
• Activation of Hyaluronidase by Metallic Salts and Compound 48/80,and Inhibitory Effect of Anti-allergic Agents on Hyaluronidase
• 270 Hyaluronidase阻害活性を指標とする医薬品の開発研究(第四報)持続性抗アレルギー剤SBT-2
• 319.光照射時におけるヒアルロニダーゼ活性に対するフェノチアジン系薬物と抗アレルギー剤の影響( 抗アレルギー療法(III)新しい抗アレルギー薬)
• Synthesis of a Tetradecapeptide corresponding to Sequence 90-103 of Bovine Adrenodoxin
• Synthesis of Two Heptapeptides corresponding to Sequences 50-56 and 90-96 of Adrenodoxin from Bovine Adrenal Cortex and Formation of Their Iron-Sulfur Complexes
• Amino Acids and Peptides. XVI. Synthesis of N^G-Tosylarginyl Peptide Derivatives-Observation of Lactam Formation of Arginyl Residue(Organic,Chemical)
• Studies on Peptides. XLI. Synthesis of the Protected Hexadecapeptide Corresponding to Positions 13 to 28 of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop)
• Studies on Peptides. XXIV. Some Observation on the Urethan Formation during the Mixed Anhydride Procedure in Peptide Synthesis
• Studies on Peptides. XXIII. Total Synthesis of Monkey β-Melanocyte-stimulating Hormone
• Studies on Peptides. XXII. Synthesis of the partially Protected Pentadecapeptide related to Monkey and Human β-Melanocyte-stimulating Hormones
• Studies on Peptides. XVI. Regeneration of Lysine from N^ε-Formyllysine by Aqueous Hydrazine or Hydroxylamine and Their Application to the Synthesis of α-Melanocyte-stimulating Hormone
• Studies on Peptides. XV. Synthesis of Prolyltyrosylarginylmethionine, the Tetrapeptide situated within the Amino Acid Sequences of Monkey and Human β-Melanocyte-stimulating Hormones.
• Studies on Peptides. XIV. Synthesis of Lysyl-S-benzylcysteinylalanylglutaminyl-S-benzyl-cysteinylhistidine, a Peptide related to Horse Heart Cytochrome C.
• Studies on Peptides. XII.Synthesis of the Decapeptide corresponding to the C-Terminal Portion of β-Melanocyte-stimulating Hormone
• Studies on Peptides. VIII. Synthesis of Two Heptapeptides Isolated from Pituitary Glands
• Studies on Peptides. VI. Synthesis of Three Stereoisomeric Pentapeptides of Histidylphenyl-alanylarginyltryptophylglycine Possessing D-Phenylalanyl-D-arginyl Moiety within the Sequence and Their Melanocyte-stimulating Activities in vitro
• Amino Acids and Peptides. XL. Synthesis of Ac-Tyr-Val-Ala-Asp-MCA Using Newly Developed Acetylating Reagent
• Amino Acids and Peptides. XXXVI. Synthesis of Enkephalin Chloromethyl Ketone and Evaluation of Its Inhibitory Activity against Endopeptidase 22.19
• Development of Active Center-Directed Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Inhibitory Activity Relationship
• Synthesis of trans-4-Aminomethylcyclohexanecarbonyl-L- and -D-phenylalanine-4-carboxymethylanilide and Examination of Their Inhibitory Activity against Plasma Kallikrein
• Amino Acids and Peptides. XXXIII. Synthesis of N-Terminal Epitope Peptides of Mammalian Metallothioneins (MTs)
• Development of Selective Inhibitors against Plasma Kallikrein
• Development of Active Center-Directed Inhibitors against Plasmin
• Synthesis of Tripeptide Chloromethyl Ketones and Examination of Their Inhibitory Effects on Plasmin and Plasma Kallikrein
• Synthesis of Active Center-Directed Prptide Inhibitors of Plasmin
• Structure and Synthesis of an Immunoactive Lipopeptide, WS1279,of Microbial Origin
• Amino Acids and Peptides. XXV. : Application of Newly Developed β-1- and β-2-Adamantylaspartates to Peptide Synthesis by Solid Phase and Conventional Solution Methods
• Amino Acids and Peptides. VI. Curtius Rearrangement of Acyl Amino Acid and Peptide Azides and Reactivity of the Isocyanates
• Synthesis of Bradykinin Fragments and Their Analogs modified at a Phenylalanine Residue
• Synthesis of a Tetradecapeptide corresponding to Sequence 50-63 of Adrenodoxin from Bovine Adrenal Cortex and Formation of Its Iron-Sulfur Complex
• Amino Acids and Peptides. III. Synthesis of Stereoisomeric Alanine Containing Peptide Derivatives and Their Effects on Germination of Bacillus thiaminolyticus Spores. (2)
• Amino Acids and Peptides. II. Synthesis of Stereoisomeric Alanine containing Peptide Derivatives and Their Effects on Germination of Bacillus thiaminolyticus Spores
• Simple Gas Chromatographic Identification of Monosaccharides Using a Curie-Point Type pyrolyzer
• コラゲナーゼ阻害剤に関する研究(第2報)アントラキノン誘導体の細菌性コラゲナーゼ阻害作用
• 脱臭処理条件の異なるヤツメ鰻油摂取マウスの血清脂質, 網内皮系及び抗体産生能に及ぼす影響
• 光力学的物質による過敏症成立とその物理化学的メカニズム
• Synthesis of Stereoisomeric Alanine Containing Peptide Derivatives
• 食品系未利用資源からのセラミックス成形助剤の作製
• 食品系未利用資源からのセラミックス成形助剤の作製 (第12回廃棄物学会研究発表会) -- (炭化処理などの資源化)
• Amino Acids and Peptides. IX. Synthesis of Cysteine-Containing Peptide Fragments Related to Human Hepatic Metallothionein II (hMT II) and Determination of Their Heavy Metal-Binding Properties
• Amino Acids and Peptides. VIII. Synthesis of a Hexacosapeptide corresponding to the C-Terminal Sequence 36-61 of Human Metallothionein II (hMT II) and Determination of Its Heavy Metal Binding Activity
• Amino Acids and Peptides. VII. Synthesis of Methionine-Enkephalin using Transfer Hydrogenation
• おからの食文化をとおして現代の食生活と環境を考える
• 3-Aminoisocarbostyril誘導体の蛍光特性 その3 イソカルボスチリル及びその類縁化合物の蛍光特性
• 3-Aminoisocarbostyril誘導体の螢光特性 その2 2-Amino-3-hydrazino-および2,3-Diamino-isocarbostyrilのヒドラゾンおよび環化成績体の発光特性
• 3-Aminoisocarbostyril誘導体の螢光特性 その1
• Amino Acids and Peptides. V. Synthesis of N-L-and D-Alanyl-1-aminoethylphosphonic Acids
• 天然薬物のSialidase活性に及ぼす影響
• 温州ミカン果皮の食品への有効利用について
• オカラの食品への有効利用--東洋医学的思想に基づいた利用
• 熱処理をしたサバ, イワシおよびヤツメウナギ油のマウスの脂質代謝および肝臓に及ぼす影響
• 薬物による光線過敏症
• 学生実習とスキンシップ(学生実習のあり方)

もっと見る 閉じる

スポンサーリンク