Protective Effects of Hydroxychalcones on Free Radical-Induced Cell Damage

概要

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A number of hydroxychalcones were synthesized to evaluate their protective effects against oxidative cell damage and the production of superoxide anion. The hydroxychalcones which have a 3,4-dihydroxycinnamoyl structure were potent inhibitors of lipid peroxidation in rat liver microsomes. In particular, we found that 2', 4', 3,4-tetrahydroxychalcone (3) exhibited a potent inhibitory effect on H_2O_2-induced hemolysis due to an antioxidant effect. In addition, this compound strongly inhibited CCl_4-induced cytotoxicity in primary cultured hepatocytes and substantially decreased the production of superoxide anion by rat peritoneal exudate macrophages.
社団法人日本薬学会の論文
1994-02-15