3-Aminoisocarbostyril誘導体の蛍光特性その3 イソカルボスチリル及びその類縁化合物の蛍光特性

概要

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The fluorescence characteristics of amino- and anilino-derivatives of isocarbostyril, isocoumarin and 4-quinazolinone were examined comparatively in connection with their molecular structures. The fluorescence maxima of these compounds significantly depended upon the partial structures in molecules such as lactam structure for isocarbostyrils and 4-quinazolinones, lactone for isocoumarins, and guanidino for amino- and anilino-4-quinazolinones. Stereochemical configuration of anilino-substituted compounds was estimated from changes in fluorescence maxima. These derivatives other than 2-anilino-4-quinazolinone (IIIc) were highly fluorescent in ethanol. In contrast, IIIc exhibited extremely low fluorescence in ethanol and was practically non-fluorescent in aqueous solution ; in less-polar solvents and aqueous protein solution, the fluorescence significantly increased. 2-Anilino-4-methoxyquinazoline (V) has also similar characteristics to those of IIIc. Therefore, IIIc and V seemed to be applicable as fluorescence probes for the investigation of hydrophobic regions in protein.
公益社団法人日本薬学会の論文
1985-02-25