N-ヘテロ芳香族の電子的性状(第58報)生物活性アミノアクリジン類とデオキシリボ核酸(DNA)との電子的相互作用 : 紫外部淡色効果

概要

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Studies were made on the ultraviolet spectral change produced by the intermolecular interaction of acridines (acridine, 1-, 3-, 4-, and 9-aminoacridines, proflavine, Acridine Yellow, and Acridine Orange) and calf thymus deoxyribonucleic acid (DNA). The mixed systems of these acridines and DNA gave a hypochromic change in the ultraviolet region. The observed hypochromisn was quantified in terms of integrated intensity, H. The value of H run parallel with bacteriostatic index of the acridines. Protonation of acridines was favorable for the production of the hypochromic change. Examinations were also made on the mode of the intermolecular interaction from the point of flow dichroism of the interaction system, change in specific viscosity, and change in the melting temperature of DNA by this interaction. It was observed that polyguanylate and polyadenylate gave ultraviolet hypochromism on mixing with acridines, but no spectral change was observed with pyrimidine homopolynucleotides. On the basis of these informations, it was presumed that the modified intercalation model is applicable to the mode of interaction under the present experimental conditions.
社団法人日本薬学会の論文
1976-11-25