N-ヘテロ芳香族の電子的性状(第55報)合成高分子によるアクリジン系医薬品のラット小腸吸収の抑制とその機構

概要

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Studies were made on the effect of polyvinylpyrrolidone (PVP) and sodium carboxymethylcellulose (CMC) on the intestinal absorption of acridine system drugs in rats, and also on molecular interaction between acridine derivatives and the polymers. It was revealed that in the case of PVP-proflavine, PVP-acrinol and CMC-acrinol systems, whose in vitro binding ratio between acridine and polymer is relatively large, the intestinal absorption of acridine derivatives is inhibited by the relevant polymers, while no significant effect of polymer is observed in the case of PVP-quinacrine, CMC-proflavine, and CMC-quinacrine systems whose binding ratio is relatively small. Experimental results suggested that hydrophobic binding and ionic binding play important parts in the interaction between PVP and acridine derivatives and between CMC and acridine derivatives, respectively.
公益社団法人日本薬学会の論文
1976-03-25