Syntheses and Inhibitory Effects on Gastric Lesions of 4-Guanidinomethylbenzoic Acid Arylamides
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概要
- 論文の詳細を見る
A novel series of 4-guanidinomethylbenzoic acid (GMBA) arylamides was synthesized. Several showed more potent inhibitory effects on stress-induced gastric lesion in rats than cetraxate. We selected 4-guanidinomethylbenzoic acid (2'-ethoxycarbonyl)phenylamide 3 for further pharmacological assessments because it had low toxicity. Compound 3 showed significant inhibitory effects on stress-, HCl-ethanol- and indomethacin-induced gastric lesions and gastric secretion, the ED_<50> values being 34.4,45.0 and 23.0mg/kg (p.o.) and 240mg/kg (i.d.), respectively. Furthermore, this compound restored the reduction of gastric mucus caused by the stress-loading and inhibited compound 48/80-induced ulcer.
- 社団法人日本薬学会の論文
- 1993-08-15
著者
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松本 仁
徳島文理大学
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掛川 寿夫
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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佐藤 利夫
徳島文理大学薬学部
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佐藤 利夫
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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松本 仁
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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掛川 寿夫
香川大学工学部
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宮高 透喜
徳島文理大学薬学部
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宮高 透喜
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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上田 浩貴
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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池田 哲之
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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松本 仁
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Sato T
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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上田 浩貴
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Kakegawa Hisao
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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松本 仁
徳島文理大 薬
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佐藤 利夫
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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池田 哲之
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Okamoto Hiroshi
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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