Inhibitory Effects of Some Natural Products on the Activation of Hyaluronidase and Their Antiallergic Actions
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概要
- 論文の詳細を見る
The anti-allergic drugs disodium cromoglycate (DSCG) and tranilast are strong inhibitors of hyaluronidase. In the development of new anti-allergic drugs, we studied the inhibitory effects of some natural products on the activation of hyaluronidase. Among the compounds tested, liquiritigenin, isoliquiritigenin and baicalein showed dose-related inhibitory effects. Anti-allergic activities of these compounds were evident from the facts that they inhibited the histamine release from rat peritoneal exudate cells induced by antigen, compound 48/80 and calcium ionophore A-23187,and from their inhibitory effect on Shultz-Dale reaction using sensitized guinea pig ileum.
- 社団法人日本薬学会の論文
- 1992-06-25
著者
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松本 仁
徳島文理大学
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掛川 寿夫
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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佐藤 利夫
徳島文理大学薬学部
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佐藤 利夫
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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松本 仁
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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掛川 寿夫
香川大学工学部
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松本 仁
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Sato T
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Kakegawa Hisao
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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松本 仁
徳島文理大 薬
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佐藤 利夫
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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Okamoto Hiroshi
Faculty Of Pharmaceutical Sciences Kobe-gakuin University
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