Antiinflammatory Activity of Heart-treated Cassia alata Leaf Extract and Its Flavonoid Glycoside
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概要
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Antiinflammatory activities of heat-treated Cassia alata leaf extract and kaempferol 3-O-gentiobioside (K3G) isolated from C. alata as an abundant flavonoid glycoside were studied by comparing their activities with the activities of sun-dried C. alata leaf extract. We observed strong inhibitory effects on Concanavalin A-induced histamine release from rat peritoneal exudate cells both in the extracts of heat-treated and sun-dried C. alata leaves. Furthermore, the heat-treated leaf extract exhibited stronger inhibitory effects than the effects of the sun-dried leaf extract at low concentrations in the studies of Concanavalin A-induced histamine release, 5-lipoxygenase inhibition, and also inhibition of cyclooxygenases (COX-1 and COX-2) , whereas K3G showed weak inhibitory effects on Concanavalin A-induced histamine release, 5-lipoxygenase, and COX-1. No anti-hyaluronidase effect was detected in any of the materials tested.
- 社団法人日本薬学会の論文
- 2003-07-01
著者
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森山 浩義
星薬科大学
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飯塚 徹
横浜薬科大学
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森山 浩義
Faculty of Pharmaceutical Sciences, Hoshi University
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飯塚 徹
Faculty of Pharmaceutical Sciences, Hoshi University
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森山永井 正博
Faculty of Pharmaceutical Sciences, Hoshi University
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宮[タカ] 透喜
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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佐藤 利夫
Faculty of Pharmaceutical Sciences, Tokushima Bunri University
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森山永井 正博
Faculty Of Pharmaceutical Sciences Hoshi University
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宮 透喜
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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佐藤 利夫
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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