3-O-Alkuylascorbic Acids as Free Radical Quenchers. II. Inhibitory Effects on Some Lipid Peroxidation Models

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We previously found that 3-O-dodecylcarbomethylascorbic acid (3-RASA, 2,HX-0112) exhibited a potent inhibitory effect on biochemical lipid peroxidation and that 3-RASA (3) alleviated myocardial lesions induced by ischemia-reperfusion treatment in rats. In this study we examined the mode of action of 3-RASA (3) on the inhibition of lipid peroxidation. There was no reducing activity by 3-RASA (3) (i.e., no oxide was produced) against ferric ions and superoxide anion radicals. The low reducing activity of 3-RASA (3) against a radical as compared to that of α-tocopherol was obtained by using a stable radical. However, 3-RASA (3) had a potent inhibitory effect, almost equal to the of α-tocopherol, in the model of lipid peroxidation dependent on enzymatic superoxide generation. 3-RASA (3) very strongly inhibited the chain-reaction of the peroxidation induced by Fe^<+2>-linoleic acid hydroxyperoxide. On the basis of these findings, it appears that the anti-lipid-peroxidative effects of 3-RASA are due to the inhibition of the radical chain-reaction, as a chain-breaking antioxidant.
社団法人日本薬学会の論文
1991-07-25