Medicinal Chemical Studies on Synthetic Protease Inhibitors, trans-4-Guanidinomethylcyclohexanecarboxylic Acid Aryl Esters
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概要
- 論文の詳細を見る
trans-4-Guanidinomethylcyclohexanecarboxylic acid (trans-GMCHA) aryl esters were synthesized and tested for inhibitory effects on serine proteases, trypsin, chymotrypsin, plasmin, plasma kallikrein, pancreatic kallikrein, urokinase and thrombin. In general, these compounds showed strong inhibitory effects on chymotrypsin, pancreatic kallikrein and urokinase, but the effects varied greatly depending on the substituent in the benzene nucleus. Some of the trans-GMCHA aryl esters strongly inhibited compound 48/80-induced histamine release from mast cells / the p-tert-butylphenyl ester was especially active.
- 1985-02-25
著者
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佐藤 利夫
徳島文理大学薬学部
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村松 暁
School Of Pharmacy Tokushima University Of Arts & Science
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宮高 透喜
徳島文理大学薬学部
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佐藤 利夫
School of Pharmacy, Tokushima University of Arts and Science
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Sato T
Faculty Of Pharmaceutical Sciences Tokushima Bunri University
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大井 康弘
School of Pharmacy, Tokushima University of Arts Science
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宮高 透喜
School of Pharmacy, Tokushima University of Arts & Science
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中嶋 俊夫
Nippon Chemiphar Co., Ltd.,
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梅山 正登
Nippon Chemiphar Co., Ltd.,
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中嶋 俊夫
Nippon Chemiphar Co. Ltd.
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大井 康弘
School Of Pharmacy Tokushima University Of Arts And Science
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梅山 正登
Nippon Chemiphar Co. Ltd.
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