Amino Acids and Peptides. XXVII. : Synthesis of Phytochelatin-Related Peptides and Examination of Their Heavy Metal-Binding Properties

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概要

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• Phytochelatin (PC)-related peptides were prepared by a conventional solution method and their heavy metal-binding properties were examined. Different from the Cu^<2+> and Cu^+-binding properties of metallothionein (MT)-related peptides, the Cu^<2+> and Cu^+-binding properties of PC-related peptides were fairly dependent on structure. It is of interest that γ-Glu-Cys-Gly (glutathione) exhibited quite different Cu^<2+> and Cu^+-binding properties from those of other PC-related peptides and its binding abilities were comparable to those of MT-related peptides. The Cd^< 2+>-binding properties of glutathione were similar to those of Cys, and the Cd^<2+>-binding abilities of PC-related peptides increased in proportion to the increase of γ-Glu-Cys peptide unit.

• 社団法人日本薬学会の論文
• 1990-09-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 閔 庚善

  Faculty of Nutrition, Kobe-Gakuin University

• 小野坂 敏見

  Faculty of Nutrition, Kobe-Gakuin University

• 田中 慶一

  Faculty of Nutrition , Kobe-Gakuin University

• 小野坂 敏見

  神戸学院大学栄養学部

• 閔 庚善

  神戸学院大学栄養学部

• 松本 良和

  Faculty of Pharmaceutical Sciences

• 岡田 芳男

  神戸学院大学 薬学部

• 松本 良和

  Faculty Of Pharmaceutical Sciences:kobe-gakuin University

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