Concentration of Metallothionein in Human Pancreas

概要

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The concentration of metallothionein (MT) in the human pancreas was determined by the Sephadex G-75 method. It was higher than 51 μg/g in 15 of 18 cases, and was in the range of 218-834 μg/g in six cases. Clear peaks of zinc and cadmium in the metallothionein fraction were observed in the elution profile of the pancreas supernatant on a Sephadex G-75 column. A positive relationship was found between zinc and metallothionein concentrations in the human pancreas (r=0.439,p<0.05), but no relationship was observed between the age of patients and MT concentration. These results indicate that metallothionein in the human pancreas is zinc, cadmium-thionein, and that the metallothionein concentration is high in most human pancreases. Metallothionein may be one of the main zinc-binding components in the human pancreas.
社団法人日本薬学会の論文
1988-04-30