Amino Acids and Peptides. XXXVI. Synthesis of Enkephalin Chloromethyl Ketone and Evaluation of Its Inhibitory Activity against Endopeptidase 22.19

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概要

• 論文の詳細を見る

• Boc-Tyr-Gly-Gly-Phe-Leu-CH_2Cl was synthesized by the conventional solution method. During the course of acid hydrolysis (6N HCl, 110℃, 18 h) of Boc-Phe-Leu-CH_2Cl, side reaction occurred, resulting in low recovery of Phe residue on amino acid analysis. The inhibitory activity of the synthesized Boc-Tyr-Gly-Gly-Phe-Leu-CH_2-Cl against endopeptidase 22.19,an enzyme related to the metabolism of opioid peptides, was examined.

• 社団法人日本薬学会の論文
• 1993-11-15

著者

• 西山 泰弘

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 岡田 芳男

  神戸学院大学 薬学部

• 田口 博明

  Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

• CAMARGO Antonio

  Department of Pharmacology, Institute of Biomedical Sciences, University of San Paulo

• 田口 博明

  Faculty Of Pharmaceutical Sciences Kobe-gakuin University

• Camargo Antonio

  Department Of Pharmacology Institute Of Biomedical Sciences University Of San Paulo

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