合成インヒビターのデザイン戦略 : 二機能性トロンビン阻害剤のデザイン

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概要

• 論文の詳細を見る
• 1998-12-01

著者

• 津田 裕子

  神戸学院大学薬学部薬品化学

• 岡田 芳男

  神戸学院大学 薬学部

• 岡田 芳男

  神戸学院大学

関連論文

• Amino Acids and Peptides. XXXV. Synthesis of Mouse Metallothionein I. (2). Synthesis of a Nonacosapeptide Corresponding to N-Terminal Sequence 1-29 (β-Fragment) of Mouse Metallothionein I and Related Peptides and Examination of Their Heavy Metal-Binding P
• Amino Acids and Peptides. XXXIV. Synthesis of Mouse Metallothionein I. (1). Synthesis of Dotriacontapeptide Corresponding to C-Terminal Sequence 30-61 (α-Fragment) of Mouse Metallothionein I and Related Peptides and Examination of Their Heavy Metal-Bindin
• Amino Acids and Peptides. XXVII. : Synthesis of Phytochelatin-Related Peptides and Examination of Their Heavy Metal-Binding Properties
• Amino Acids and Peptides. XXVI. Synthesis of Agaricus bisporus Metallothionein and Related Peptides and Examination of Their Heavy Metal-Binding Properties
• Amino Acids and Peptides. XXIV. : Synthesis of Neurospora crassa Metallothionein and Related Cysteine-Containing Peptides and Examination of Their Heavy Metal-Binding Properties
• Amino Acids and Peptides. XIII. : Synthesis of a Nonacosapeptide Corresponding to the N-Terminal Sequence 1-29 (β-Fragment) of Human Liver Metallothionein II (hMT II) and Its Heavy Metal-Binding Properties
• Amino Acids and Peptides. XXI. : Synthesis of N-Terminal Heptapeptide of Mammalian Metallothionein (MT) and Evaluation of Its Immunoreactivity
• Amino Acids and Peptides. XXXVII. Synthesis of Stereoisomeric Nonapeptides Corresponding to Sequence 41-49 of Eglin c and Examination of Their Inhibitory Activity against Human Leukocyte Cathepsin G and α-Chymotrypsin
• Application of Poly-L-lysine to Purification of Leukocyte Cathepsin G by Affinity Chromatography
• Amino Acids and Peptide. XXX. Synthesis of Eglin c (41-49) and Eglin c (60-63) and Examination of Their Inhibitory Activity towards Human Leukocyte Elastase, Cathepsin G, Porcine Pancreatic Elastase and α-Chymotrypsin
• Amino Acids and Peptides. XXIX. Synthesis of Peptide Fragments Related to Active Center of Eglin c and Studies on the Relationship between Their Structure and Their Inhibitory Activity against Cathepsin G and α-Chymotrypsin
• Amino Acids and Peptides. XXVIII. : Synthesis of Peptide Fragments Related to Eglin c and Studies on the Relationship between Their Structure and Effects on Human Leukocyte Elastase, Cathepsin G and α-Chymotrypsin
• Amino Acids and Peptides. XXII. : Synthesis of Substrates and Inhibitors of Human Leukocyte Cathepsin G
• Synthesis of Tripeptide Amide Derivatives and Examination of Their Inhibitory Effect on Human Leukocyte Elastase (HLE)
• Inhibition of α-Chymotrypsin by Suc-L-Tyr-D-Leu-D-Phe-pNA, a Stereoisomer of a Specific Substrate
• Synthesis of Chromogenic Substrates Specific for Human Spleen Fibrinolytic Proteinase (SFP) and Human Leukocyte Elastase (LE)
• CONVENIENT PURIFICATION OF HUMAN SPLEEN FIBRINOLYTIC PROTEINASE (SFP) AND HUMAN LEUCOCYTE ELASTASE BY AFFINITY CHROMATOGRAPHY
• Stereoisomeric Alanine Peptides as Substrates for Human Spleen Fibrinolytic Proteinase (SFP)
• Synthesis of Stereoisomeric Suc-Tyr-Leu-Val-pNA and Their Properties as Substrate and Inhibitor for Human Spleen Fibrinolytic Proteinase (SFP)
• Human Chorionic Gonadotropin. III. Synthesis of a Dotriacontapeptide corresponding to the C-Terminal Sequence 116-147 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
• Human Chorionic Gonadotropin. II. Synthesis of a Hexadecapeptide corresponding to the C-Terminal Sequence 132-147 of the β-Subunit of Human Chorionic Gonadotropin (hCG)
• Synthesis of C-Terminal Peptides of the β-Subunit of Human Chorionic Gonadotropin (hCG)
• Amino Acids and Peptides. XXXIX. Synthesis of iNoc-Gln-Val-Val-Ala-Ala-pNA and Its Action on Thiol Proteinases
• 中国製薬企業のR&Dとナレッジマネジメントに関する追跡調査
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• Amino Acids and Peptides. XL. Synthesis of Ac-Tyr-Val-Ala-Asp-MCA Using Newly Developed Acetylating Reagent
• Amino Acids and Peptides. XXXVI. Synthesis of Enkephalin Chloromethyl Ketone and Evaluation of Its Inhibitory Activity against Endopeptidase 22.19
• Development of Active Center-Directed Plasmin and Plasma Kallikrein Inhibitors and Studies on the Structure-Inhibitory Activity Relationship
• Synthesis of trans-4-Aminomethylcyclohexanecarbonyl-L- and -D-phenylalanine-4-carboxymethylanilide and Examination of Their Inhibitory Activity against Plasma Kallikrein
• Amino Acids and Peptides. XXXIII. Synthesis of N-Terminal Epitope Peptides of Mammalian Metallothioneins (MTs)
• Development of Selective Inhibitors against Plasma Kallikrein
• Development of Active Center-Directed Inhibitors against Plasmin
• Synthesis of Tripeptide Chloromethyl Ketones and Examination of Their Inhibitory Effects on Plasmin and Plasma Kallikrein
• Synthesis of Active Center-Directed Prptide Inhibitors of Plasmin
• Structure and Synthesis of an Immunoactive Lipopeptide, WS1279,of Microbial Origin
• STRUCTURE AND SYNTHESIS OF AN IMMUNOACTIVE LIPOPEPTIDE, WS1279,OF MICROBIAL ORIGIN
• Amino Acids and Peptides. XXV. : Application of Newly Developed β-1- and β-2-Adamantylaspartates to Peptide Synthesis by Solid Phase and Conventional Solution Methods
• Isolation and Identification of Self-Transfer Products Formed by Guinea Pig Liver β-Mannosidase(Organic,Chemical)
• Amino Acids and Peptides. VI. Curtius Rearrangement of Acyl Amino Acid and Peptide Azides and Reactivity of the Isocyanates
• Synthesis of Bradykinin Fragments and Their Analogs modified at a Phenylalanine Residue
• Synthesis of a Tetradecapeptide corresponding to Sequence 50-63 of Adrenodoxin from Bovine Adrenal Cortex and Formation of Its Iron-Sulfur Complex
• 1-I-18 好酸球遊走因子に対するアラキドン酸過酸化物およびBSA脂質の影響(第38回大会研究発表要旨,日本ビタミン学会)
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• Amino Acids and Peptides. XX. : Inhibition of Papain by Succinyl-Gln-Val-Val-Ala-p-Nitroanilide, a Common Sequence of Endogenous Thiol Proteinase Inhibitors
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