Stereoisomeric Alanine Peptides as Substrates for Human Spleen Fibrinolytic Proteinase (SFP)

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概要

• 論文の詳細を見る

• Four kinds of stereoisomeric Z-Ala-Ala-OMe and eight kinds of stereoisomeric Z-Ala-Ala-Ala-OMe were tested as substrates for human spleen fibrinolytic proteinase (SFP) in comparison with porcine pancreatic elastase. Both enzymes exhibited esterase activity towards not only Z-L-Ala-L-Ala-L-Ala-OMe (VI) but also Z-D-Ala-L-Ala-L-Ala-OMe (VII). The rate of esterolysis of VI by elastase was only about twice the rate of esterolysis by SFP although the rate of amidolysis of Suc-L-Ala-L-Ala-L-Ala-pNA (XVI) by elastase was tenfold faster than that by SFP.

• 社団法人日本薬学会の論文
• 1981-06-25

著者

• 岡田 芳男

  Faculty of Pharmaceutical Sciences Kobe-Gakuin University

• 津田 裕子

  Faculty of Pharmaceutical Sciences

• 永松 陽子

  Faculty Of Nutrition Kobe-gakuin University

• 岡本 歌子

  Faculty of Pharmaceutical Sciences

• 津田 裕子

  神戸学院大学薬学部薬品化学

• 岡本 歌子

  血栓止血研究神戸プロジェクト

関連論文

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