Studies on Peptides. VI. Synthesis of Three Stereoisomeric Pentapeptides of Histidylphenyl-alanylarginyltryptophylglycine Possessing D-Phenylalanyl-D-arginyl Moiety within the Sequence and Their Melanocyte-stimulating Activities in vitro
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概要
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The syntheses of three pentapeptide isomers, L-histidyl-D-phenylalanyl-D-arginyl-L-tryptophylglycine (II), D-histidyl-D-phenylalanyl-D-arginyl-L-tryptophylglycine (III) and L-histidyl-D-phenylalanyl-D-arginyl-D-tryptophylglycine (IV) were described. N^α-Ben-zyloxycarbonyl-D-phenylalanyl-N^G-nitro-D-arginine served as a key intermediate for the synthesis of these isomers. Melanocyte-stimulating activities of these compounds were examined using the frog-skin from Rana pipiens. It was found that II possessed the activity identical to that of L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycine (I). The peptides (III) and (IV) were both inactive.
- 社団法人日本薬学会の論文
- 1965-11-25
著者
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岡田 芳男
Faculty of Pharmaceutical Sciences Kobe-Gakuin University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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久保 一雄
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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久保 一雄
Faculty Of Pharmaceutical Sciences Kyoto University
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