Studies on Peptides. LVII. Synthesis of the Octadecapeptide corresponding to the Entire Amino Acid Sequence of Equine β-Melanocyte-stimulating Hormone

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概要

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• The octadecapeptide corresponding to the entire amino acid sequence of equine β-melanocyte-stimulating hormone (MSH) was synthesized by assembling 4 subunits ; Z (OMe)-Asp (OBzl)-Glu (OBzl)-Gly-OH (I), Z (OMe)-Pro-Tyr-Lys (Z)-Met-NHNH_2 (II), Z (OMe)-Glu (OBzl)-His-Phe-Arg (Tos)-Trp-Gly-OH (III), Z (OMe)-Ser-Pro-Arg (Tos)-Lys(Z)-Asp (OBzl)_2 (IV), followed by deblocking of all protecting groups with hydrogen fluoride. The in vivo MSH activity of synthetic equine β-MSH was found equivalent to that of synthetic human β-MSH (in vitro activity, 6.2×10^9 MSH unit/g).

• 社団法人日本薬学会の論文
• 1975-10-25

著者

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 中村 益久

  Shionogi Research Laboratories, Shionogi & Co., Ltd.,

• 木曾 良明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 田中 明

  Shionogi Research Laboratory Shionogi And Co. Ltd.

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 中村 益久

  Shionogi Research Laboratories Shionogi & Co. Ltd.

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