Studies on Peptides. LXXIII. Examination of the Methanesulphonic Acid Procedure for the Synthesis of Peptides containing Methionine
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概要
- 論文の詳細を見る
Aromatic ethers, such as anisole or phenetole, were cleaved smoothly with methanesulphonic acid (MSA) or trifluoromethanesulphonic acid in the presence of Met to form methionine-S-methyl (or ethyl) sulphonium salt (I). When the protecting group of Z-Met-OH or Boc-Met-OH was cleaved in the MSA-anisole system, (I) was found as a major product, besides a samll amount of S-benzyl or S-tert-butyl derivative. Thus a Met-containing peptide, H-Tyr-Gly-Gly-Gly-Lys-Met-Gly-OH named endorphin, was synthesized after deprotection of Z (OMe)-Tyr-Gly-Gly-Gly-Lys (Z)-Met (O)-Gly-OH by the MSA-anisole procedure followed by reduction of the Met (O) moiety to the parent amino acid residue with dithiothreitol.
- 社団法人日本薬学会の論文
- 1977-11-25
著者
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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小川 博
Faculty Of Pharmaceutical Sciences Kyoto University
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入江 寛
Faculty of Pharmaceutical Sciences, Nagasaki University
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藤野 政彦
武田薬品工業
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藤野 政彦
Faculty of Pharmaceutical Sciences, Kyoto University
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品川 進
Faculty of Pharmaceutical Sciences, Kyoto University
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入江 寛
長崎大学薬学部
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入江 寛
Faculty Of Pharmaceutical Sciences Kyoto University
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藤野 政彦
武田薬品中央研
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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