Studies on Peptides. CXX. Synthesis of Growth Hormone Releasing Factor (GRF-37-NH_2) and N^α-Biotinyl-GRF-44-NH_2
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概要
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The amide form of the heptatriacontapeptide corresponding to the entire amino acid sequence of one of the human pancreatic tumor-derived peptides, termed growth hormone releasing factor (hpGRF), was synthesized in a conventional manner using a thioanisole-mediated deprotection procedure. In in vivo assay, this peptide (hpGRF-37-NH_2) was as active as the synthetic tetratetracontapeptide amide (hpGRF-44-NH_2). However, in in vitro assay, the potency of synthetic hpGRF-37-NH_2 was only 15% of that of synthetic hpGRF-44-NH_2. In addition, N^α-biotinyl-GRF-44-NH_2 was prepared for histochemical receptor studies. This GRF-derivative exhibited approximately 60% of the activity of hpGRF-44-NH_2.
- 公益社団法人日本薬学会の論文
- 1984-03-25
著者
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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吉武 彬
Institute For Biological Sciences Sumitomo Chemical Co. Ltd.
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庄野 文章
Institute For Biological Sciences Sumitomo Chemical Co. Ltd.
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庄野 文章
住友化学工業
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矢島 治明
京都大学
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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霜倉 正徳
Faculty of Pharmaceutical Sciences, Kyoto University
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津田 正文
Institute for Biological Sciences, Sumitomo Chemical Co., Ltd.
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津田 正文
Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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霜倉 正徳
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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霜倉 正徳
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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津田 正文
Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.
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