Studies on Peptides. CLVI. Synthesis of Second Human Calcitonin Gene-Related Peptide (β-hCGRP) by Application of a New Disulfide-Bonding Reaction with Thallium(III) Trifluoroacetate(Organic,Chemical)

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概要

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• A 37-residue peptide corresponding to the entire amino acid sequence of second human calcitonin gene-related peptide (β-hCGRP) was synthesized by assembling seven peptide fragments, followed by two successive treatments; i.e., first with thallium(III) trifluoroacetate to establish the disulfide bond between two Cys(Ad) residues and then with 1 M trimethylsilyl trifluoromethane-sulfonate/trifluoroacetic acid in the presence of diphenyl sulfide and ammonium iodide to remove all protecting groups employed and at the same time to reduce Met(O) to Met. The result was compared with that obtained by the usual air-oxidation procedure. Synthetic β-hCGRP exhibited a weak inhibitory action against bone Ca-resorption stimulated by [1-34]-parathyroid hormone in vitro and lowered the Ca and Pi levels in rat serum.

• 社団法人日本薬学会の論文
• 1987-12-25

著者

• 藤井 信孝

  京都大学薬学部

• 大高 章

  Faculty of Pharmaceutical Sciences, Kyoto University

• 藤井 信孝

  Faculty of Pharmaceutical Sciences, Kyoto University

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 別所 清

  Faculty Of Pharmaceutical Sciences Kyoto University

• 野田 俊治

  Research Laboratory Toyo Jozo Co. Ltd.

• 山本 逸雄

  Faculty of Medicine, Kyoto University

• 山本 逸雄

  Department Of Radiology School Of Medicine:kyoto University

• 大高 章

  徳島大学大学院ヘルスバイオサイエンス研究部

• 大高 章

  京都大学 薬

• 大高 章

  京大 大学院薬学研究科

• 渡辺 俊博

  Faculty of Pharmaceutical Sciences, Kyoto University

• 矢島 治明

  京都大学

• 矢島 治明

  京大・薬

• 藤井 信孝

  京大 薬

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 渡辺 俊博

  Faculty Of Pharmaceutical Sciences:kyoto University

• 藤井 信孝

  京都大学

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