Apparent Autolysis of the N-Terminal Tetrapeptide of Vasoactive Intesinal polypeptide (VIP)
スポンサーリンク
概要
- 論文の詳細を見る
The hydrolysis of a tetrapeptide, H-His-Ser-Asp-Ala-OH, corresponding to the N-terminal portion of vasoactive intestinal polypeptide (VIP) was examined. At pH 5.0,Ala was released at a much faster rate than His, while the release of His was predominant at pH 7.78. When examined by nuclear magnetic resonance spectroscopy, the pD dependence of chemical shift was especially pronounced at the His residue, but in a different manner from that observed in a His monomer. On the basis of calculation of rotamer population ratios, a relationship between the predominant G' conformation of the His residue and faster hydrolysis of the tetrapeptide at lower pH is postulated.
- 公益社団法人日本薬学会の論文
- 1983-03-25
著者
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木山 晋哉
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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武山 正治
Department of Clinical Pharmacy, Oita Medical University
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武山 正治
Faculty of Pharmaceutical Sciences, Kyoto University
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武山 正治
Department Of Clinical Pharmacy Oita Medical University
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矢島 治明
京都大学
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矢島 治明
京大・薬
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西 則雄
Faculty Of Science Hokkaido University
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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堤 耀広
Faculty of Science, Hokkaido Unversity
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森重 正也
Faculty of Science, Hokkaido Unversity
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堤 耀広
Faculty Of Science Hokkaido Unversity
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森重 正也
Faculty Of Science Hokkaido Unversity
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