Synthesis of Canine Motilin, a Gastric Motor Activity-Stimulating Polypeptide, and Its N^1-Substituted Analogs

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概要

• 論文の詳細を見る

• The docosapeptide corresponding to the entire amino acid sequence of canine motilin, a newly characterized gastric motor activity-stimulating polypeptide, was synthesized by the conventional solution method. All protecting groups employed were removed by 1 M trifluoromethanesulfonic acid-thioanisole-trifluoroacetic acid and the deprotected peptide was purified by gel-filtration on Sephadex G-25,followed by partition chromatography and reverse phase high performance liquid chromatography. When contractile activity on rabbit duodenal muscle was examined, synthetic canine motilin was as active as synthetic porcine motilin. The relative potencies of Lys^1 and Ser^1 derivatives prepared in the same manner as canine motilin were ca. 1/1000 and 1/250,respectively.

• 公益社団法人日本薬学会の論文
• 1985-08-25

著者

• 木山 晋哉

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 北川 幸己

  徳島大学薬学部

• 井上 敦子

  Faculty Of Pharmaceutical Sciences School Of Medicine Hiroshima University

• 安藤 健司

  Faculty of Pharmaceutical Sciences, Tokushima University

• 秋田 正

  Faculty of Pharmaceutical Sciences, Tokushima University

• 秋田 正

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 安藤 健司

  Faculty Of Pharmaceutical Sciences Tokushima University

• 瀬川 富朗

  Institute of Pharmaceutical Sciences, Hiroshima University

• 瀬川 富朗

  Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine

• 川元 達彦

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

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