Synthesis and Biological Activity of 8-L-Ala-Motilin and 8-D-Ala-Motilin
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概要
- 論文の詳細を見る
Two analogs of porcine motilin altered at position 8,[L-Ala^8]-motilin and [D-Ala^8]-motilin, were prepared by the conventional solution method via the corresponding sulfoxides (Met^<13>) and evaluated in vitro for the ability to contract the duodenal muscle of rabbit. The D-Ala analog exhibited a higher potency than synthetic motilin, whereas substitution of glycine at position 8 with L-alanine decreased the biological activity to approximately 30% relative to the synthetic motilin.
- 社団法人日本薬学会の論文
- 1978-03-25
著者
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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藤野 政彦
Pharmaceutical Research Division Takeda Chemical Industries Ltd.
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藤野 政彦
武田薬品工業
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藤野 政彦
Chemistry Laboratories Central Research Division Takeda Chemical Industries Ltd.
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大熊 康修
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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藤野 政彦
武田薬品中央研
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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瀬川 富朗
Institute Of Pharmaceutical Sciences Hiroshima University School Of Medicine
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