Studies on Peptides. CXXXIX. : Solution Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Human Glucose-Dependent Insulinotropic Polypeptide (GIP)
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概要
- 論文の詳細を見る
Eight peptide fragments were prepared by known amide-forming reactions as building blocks for the solution synthesis of the dotetracontapeptide corresponding to the entire amino acid sequence of human intestinal GIP (gastric inhibitory polypeptide or glucose-dependent insulinotropic polypeptide). Besides Lys(Z), Trp(Mts) and Gln-OBzl, two new amino acid derivatives, Asp(OChp) and Glu(OChp) [Mts=mesitylenesulfonyl, Chp=cycloheptyl], were employed to suppress various side reactions. These fragments were successively assembled by the azide procedure to minimize racemization and all protecting groups employed were removed from the protected GIP by using 1M trifluoromethanesulfonic acid-thioanisole in trifluoroacetic acid.Synthetic GIP exhibited a significant glucose-dependent insulinotropic activity in dogs, but failed to produce any notable anti-gastric activity in rats.
- 社団法人日本薬学会の論文
- 1986-06-25
著者
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藤井 信孝
京都大学薬学部
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細谷 亮
京都大学第一外科
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藤井 信孝
Faculty of Pharmaceutical Sciences, Kyoto University
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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水田 和彦
First Department Of Internal Medicine Faculty Of Medicine:kyoto University
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桜井 満也
Exploratory Chemistry Research, Sankyo Co., Ltd.,
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野水 基義
Faculty of Pharmaceutical Sciences
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赤路 健一
Faculty of Pharmaceutical Sciences
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桜井 満也
Exploratory Chemistry Research Sankyo Co. Ltd.
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桜井 満也
Faculty of Pharmaceutical Sciences, Kyoto University
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青野 充
First Department of Internal Medicine, Faculty of Medicine
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森賀 本幸
First Department of Internal Medicine, Faculty of Medicine
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井上 一知
First Department of Internal Medicine, Faculty of Medicine
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細谷 亮
First Department of Internal Medicine, Faculty of Medicine
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戸部 隆吉
First Department of Surgery, Faculty of Medicine
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野水 基義
Faculty Of Pharmaceutical Sciences Kyoto University
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矢島 治明
京都大学
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矢島 治明
京大・薬
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藤井 信孝
京大 薬
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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藤井 信孝
京都大学
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赤路 健一
Faculty Of Pharmaceutical Sciences Kyoto University
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