Synthesis of Protegrin-Related Peptides and Their Antibacterial and Anti-human Immunodeficiency Virus Activity

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概要

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• All disulfide analogs (types I, II and III) of protegrin (PG)-1,an 18-residue antimicrobial peptide having two intramolecular disulfide bonds, were synthesized using regioselective disulfide bond formation. Random air-oxidation of the fully reduced PG-1 formed the type III PG-1. In addition, a type III analog containing an amidated carboxy-terminal residue was also prepared. Each analog showed significant and different antibacterial and anti-human immunodeficiency virus (HIV) activity. Deletion of two disulfide bridges caused a significant decrease in activity.

• 社団法人日本薬学会の論文
• 1995-05-15

著者

• 山本 直樹

  感染研

• 井深 俊郎

  Faculty of Pharmaceutical Sciences, Kyoto University

• 玉村 啓和

  Faculty of Pharmaceutical Sciences, Kyoto University

• 大高 章

  Faculty of Pharmaceutical Sciences, Kyoto University

• 高田 渉

  Faculty of Pharmaceutical Sciences, Kyoto University

• 脇 道典

  SEIKAGAKU Corporation

• 藤井 信孝

  Faculty of Pharmaceutical Sciences, Kyoto University

• 村上 努

  Tokyo Medical and Dental University School of Medicine

• 山本 直樹

  Tokyo Medical and Dental University School of Medicine

• 玉村 啓和

  東医歯大生材工研

• 堀内 三吉

  Tokyo Medical and Dental University, School of Medicine

• 杉原 敬二

  Faculty of Pharmaceutical Sciences, Kyoto University

• 脇 道典

  Japan and SEIKAGAKU Corporation

• 杉原 敬二

  Faculty Of Pharmaceutical Sciences Kyoto University

• 玉村 啓和

  東京医歯大・生材研

• 大高 章

  徳島大学大学院ヘルスバイオサイエンス研究部

• 大高 章

  京都大学 薬

• 藤井 信孝

  京都大学大学院薬学研究科 医薬創成情報科学専攻

• WAKI Michinori

  SEIKAGAKU Corp.

• 大高 章

  京大 大学院薬学研究科

• 井深 俊郎

  Faculty Of Pharmaceutical Sciences Kyoto University

• 堀内 三吉

  Tokyo Medical And Dental University School Of Medicine

• Tamamura Hirokazu

  Faculty Of Pharmaceutical Sciences Kyoto University

• Tamamura Hirokazu

  Dept. Of Molecular Recognition Inst. Of Biomaterials And Bioengineering Tokyo Medical And Dental Uni

• Murakami T

  Department Of Microbiology Tokyo Medical And Dental University School Of Medicine

• 高田 渉

  Faculty Of Pharmaceutical Sciences Kyoto University

• Tamamura H

  Faculty Of Pharmaceutical Sciences Kyoto University

• Sugihara Keiji

  Faculty Of Pharmaceutical Sciences Kyoto University

• Tamamura H

  Graduate School Of Pharmaceutical Sciences Kyoto University

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