Lignified Materials as Medicinal Resources. V. Anti-HIV (Human Immunodeficiency Virus) Activity of Some Synthetic Lignins)

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概要

• 論文の詳細を見る

• A class of synthetic lignins (dehydrogenation polymers of p-coumaric acid, ferulic acid, and caffeic acid) inhibited cytopathogenicity of HIV-1 and HIV-2 infection. The ratio of cytotoxic to anti-HIV (human immunodeficiency virus) doses depended strongly on conditions during polymer preparation. The activity increased when polymers were treated with reducing agent NaBH_4,whereas it decreased when treated with oxidizing agent ceric ammonium mitrate. The polymers inhibited expression of HIV-specific antigen in the infected cells and also inhibited HIV-binding to the cells, but not completely, even at doses that almost completely inhibited the HIV-induced cytopathogenic effect. These results suggest that lignin structure, regardless of whether synthetic or natural, may inhibit HIV replication by an unidentified process, and thus prove to be a new class of anti-HIV agents possibly effective in the treatment of AIDS (acquired immunodeficiency syndrome).

• 社団法人日本薬学会の論文
• 1992-08-25

著者

• 山本 直樹

  感染研

• 中島 秀喜

  Department Of Microbiology Yamanashi Medical University

• 直江 智子

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 川添 豊

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 坂上 宏

  1st Department of Biochemistry, Showa University School of Medicine

• 中島 秀喜

  School of Medicine, Tokyo Medical and Dental University

• 村上 努

  School of Medicine, Tokyo Medical and Dental University

• 山本 直樹

  School of Medicine, Tokyo Medical and Dental University

• KONNO Kunio

  Jonan General Hospital

• 川添 豊

  名古屋市立大学薬学部

• 坂上 宏

  昭和大学第一生化学

• 川添 豊

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 坂上 宏

  1st Department Of Biochemistry School Of Medicine Showa University

• 直江 智子

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Nakashima H

  Department Of Microbiology Yamanashi Medical University

• Murakami T

  Department Of Microbiology Tokyo Medical And Dental University School Of Medicine

• Nakashima H

  Faculty Of Pharmaceutical Sciences Nagoya City University

• Konno K

  Jonan General Hospital

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