Studies on Hydrogen Exchange. XIV. Selective Hydrogen-Deuterium Exchange in Aliphatic Amines and Amino Acids catalyzed by Platinum
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概要
- 論文の詳細を見る
Various classes of aliphatic amines including amino acids were catalytically deuterated in D_2O in the presence of Adams platinum at 30°and 100°. The positions deuterated depended on the chemical structure of the amino nitrogen ; α-hydrogens were the most stable in primary amines, while they were the most labile in tertiary amines. The reaction profile of secondary amines seems to be intermediate between those of primary and tertiary amines. Quaternary amines did not react under the reaction condition studied. A tentative reaction mechanism was proposed.
- 公益社団法人日本薬学会の論文
- 1977-12-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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前田 満和
National Cancer Center Research Institute
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