LIGNIFIED MATERIALS AS MEDICINAL RESOURCES. VI. ANTI-HIV ACTIVITY OF DEHYDROGENATION POLYMER OF p-COUMARIC ACID, A SYNTHETIC LIGNIN, IN A QUASI-IN-VIVO ASSAY SYSTEM AS AN INTERMEDIARY STEP TO CLINICAL TRIALS
スポンサーリンク
概要
- 論文の詳細を見る
After the dehydrogenation polymer of p-coumaric acid, a synthetic lignin, was intravenously injected into mice, the serum was collected immediately, 15 min, 1 h, 5 h, and 24 h after the injection. The serum thus obtained was added to the assay medium containing MT-4 cells infected with HTLV-IIIB (an HIV-1 strain). Inhibition of the cytopathogenicity of HIV by these serum preparations was assayed by the MTT method. The result revealed that lignins could be a promising class of anti-HIV agents with an unidentified unique mode of action.
- 社団法人日本薬学会の論文
- 1993-04-15
著者
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山本 直樹
感染研
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中島 秀喜
Department Of Microbiology Yamanashi Medical University
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清水 直明
Faculty of Pharmaceutical Sciences, Nagoya City University
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直江 智子
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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坂上 宏
1st Department of Biochemistry, Showa University School of Medicine
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中島 秀喜
Tokyo Medical and Dental University School of Medicine
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村上 努
Tokyo Medical and Dental University School of Medicine
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山本 直樹
Tokyo Medical and Dental University School of Medicine
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川添 豊
名古屋市立大学薬学部
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坂上 宏
昭和大学第一生化学
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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坂上 宏
1st Department Of Biochemistry School Of Medicine Showa University
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直江 智子
Faculty Of Pharmaceutical Sciences Nagoya City University
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Nakashima H
Department Of Microbiology Yamanashi Medical University
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Murakami T
Department Of Microbiology Tokyo Medical And Dental University School Of Medicine
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Nakashima H
Faculty Of Pharmaceutical Sciences Nagoya City University
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清水 直明
Faculty Of Pharmaceutical Sciences Nagoya City University
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