METABOLITES OF QUINOLINE, A HEPATOCARCINOGEN, IN A SUBCELLULAR MICROSOMAL SYSTEM

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概要

• 論文の詳細を見る

• It was evidenced that quinoline was metabolized to quinoline 1-oxide catalyzed by cytochrome P-450-linked mixed function monooxygenase system and to 5,6-trans-dihydroxy-5,6-dihydroquinoline by cytochrome P-448-linked one. The third metabolite, 3-hydroxyquinoline, may be produced in another course of metabolism, which might be connected with genotoxicity of quinoline, as previously discussed.

• 公益社団法人日本薬学会の論文
• 1982-10-25

著者

• 川添 豊

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 高橋 和彦

  横浜薬科大学

• 高橋 和彦

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 川添 豊

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 高橋 和彦

  名市大 院

• 高橋 和彦

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 多田 万里子

  Laboratory of Biochemistry, Aichi Cancer Center Research Institute

• 多田 万里子

  Laboratory Of Biochemistry Aichi Cancer Center Research Institute

• 高橋 和彦

  Faculty of Agriculture, Department of Horticulture, University of Tokyo

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