Lignified Materials as Potential Medicinal Resources.III. : Diversity of Biological Activity and Possible Molecular Species Involved
スポンサーリンク
概要
- 論文の詳細を見る
Diverse biological activities of hot-water and alkali extracts of lignified materials were reviewed and the molecular species involved are discussed. Materials tested included pine cone of Pinus parviflora SIEB. et ZUCC., wood chips of slash pine, Douglas fir, and tallow wood, and two basidiocarps, in addition to their partially degraded preparations and commercial lingnins. As a tentative conclusion, the lignin structure of these extracts mights be responsible for the potent stimulation of granulocytic cell iodination, inhibition of viral infection and/or proliferation in vitro, and inactivation of viral ribonucleic acid (RNA)-dependent RNA polymerase and (adenosine diphosphate-ribose)_n glycohydrolase. Other activities displayed by some of these extracts, such as antibacterial and antitumor activities, induction of hemolytic plaque-forming-cells in mice, and stimulation of deoxyribonucleic acid synthesis of isolated splenocytes, remain to be investigated.
- 公益社団法人日本薬学会の論文
- 1990-11-25
著者
-
川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
-
坂上 宏
1st Department of Biochemistry, Showa University School of Medicine
-
川添 豊
名古屋市立大学薬学部
-
大原 利成
Faculty of Pharmaceutical Sciences, Nagoya City University
-
川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
-
坂上 宏
1st Department Of Biochemistry School Of Medicine Showa University
-
大原 利成
Faculty Of Pharmaceutical Sciences Nagoya City University
関連論文
- 抗生物質の効果比較のための新しい方法
- LIGNIFIED MATERIALS AS MEDICINAL RESOURCES. VI. ANTI-HIV ACTIVITY OF DEHYDROGENATION POLYMER OF p-COUMARIC ACID, A SYNTHETIC LIGNIN, IN A QUASI-IN-VIVO ASSAY SYSTEM AS AN INTERMEDIARY STEP TO CLINICAL TRIALS
- Lignified Materials as Medicinal Resources. V. Anti-HIV (Human Immunodeficiency Virus) Activity of Some Synthetic Lignins)
- Studies on Chemical Carcinogens and Mutagens. XXXIX. : Effects of Silicon and Germanium Substitutions on Physicochemical Properties and Cytotoxicity of N-Alkyl-N-nitrosoureas
- 医薬分業における薬学教育のあり方
- Some Cytotoxicological Aspects of Ethyl and Fluoroethyl Alkanesulfonates in Escherichia coli : Role of Fluorine Substitution
- Lignified Materials as a Potential Medicinal Resource. IV. Dehydrogenation Polymers of Some Phenylpropenoids and Their Capacity to Stimulate Polymorphonuclear Cell Iodination
- Formation of O^6,7-Dimethylguanine Residues in Calf Thymus Deoxyribonucleic Acid Treated with Carcinogenic N-Methyl-N-nitrosourea in Vitro
- Singlet Oxygen Takes Part in 8-Hydroxydeoxyguanosine Formation in Deoxyribonucleic Acid Treated with the Horseradish Peroxidase-H_2O_2 System
- LIGNIFIED NATURAL PRODUCTS AS POTENTIAL MEDICAL RESOURCES. : I POTENTIATION OF HEMOLYTIC PLAQUE-FORMING CELL PRODUCTION IN MICE
- Enhanced Cytotoxicity in Simultaneous and Sequential Drug-Heat Treatments of Cultured Chinese Hamster V79 Cells
- Deoxyribonucleic Acid (DNA) Damage Induced by Bleomycin-Fe(II) in Vitro : Formation of 8-Hydroxyguanine Residues in DNA
- DEPRIVATION OF THE MUTAGENIC PROPERTY OF QUINOLINE : INHIBITION OF MUTAGENIC METABOLISM BY FLUORINE SUBSTITUTION
- Potentiation of the Cytotoxic Activity of Anti-cancer Drugs against Cultured L1210 Cells by Bacillus thuringiensis subsp. israelensis Toxin
- Cytotoxicity of Fluorine-Containing Alkyl Alkanesulfonates to Cultured Leukemia L1210 Cells
- SYNERGISTIC EFFECT OF GLYCEROL ON CYTOTOXICITY OF BLEOMYCIN IN CULTURED CHINESE HAMSTER V79 CELLS
- Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N',N'-dimethyl-N-nitrosourea(Biological)
- Studies on Chemical Carcinogens and Mutagens. XL. : Chemoselectivity of Acylating Agents toward Aniline in Aqueous Medium
- SYNTHESIS OF 7-AMINOGUANOSINE AND ITS CONVERSION TO 8-SUBSTITUTED DERIVATIVES
- Studies on Chemical Carcinogens and Mutagens. XXXVII. : A Simple Method to Predict Ultimate Structures of Chemical Mutagens, and Probably Carcinogens
- Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N',N'-dimethyl-N-nitrosourea(Biological)
- Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N',N'-dimethyl-N-nitrosourea(Biological)
- 薬学100年
- Studies on Chemical Carcinogens. XVIII. Acetylation of Carcinogenic 4-(N-Hydroxy-N-methylamino) quinoline 1-Oxide
- 薬学教育モデルカリキュラム作成に当っての考え方 : 薬学教育、薬剤師教育に関する基本姿勢
- The Structure of Nobilonine. The Second Alkaloid from Dendrobium nobile
- The Structure of Dendrobine
- Voltammetric and Spectroscopic Studies on the Carcinogen 4-(Hydroxyamino)quinoline N-Oxide and Its Analogues(Physical,Chemical)
- 有機化学的にみた発癌因子--物質の化学構造と発癌性
- 化学発癌物質とそのメカニズム
- Metabolism of Mutagenicity-Deprived 3-Fluoroquinoline : Comparison with Mutagenic Quinoline
- Effect of Metal Ions on Transcription of the ada Gene Which Encodes O^6-Methylguanine-DNA Methyltransferase of Escherichia coli
- Studies on Chemical Carcinogens. XXIV. mutagenic Potency of Alkylated 4-Nitroquinoline 1-Oxides : Its Dependence on the Rate of Metabolic Activation
- METABOLITES OF QUINOLINE, A HEPATOCARCINOGEN, IN A SUBCELLULAR MICROSOMAL SYSTEM
- Studies on Chemical Carcinogens. XXI. Quantitative Structure-Mutagenicity Relationship among Substituted Styrene Oxides
- Studies on Chemical Carcinogens. XX. Inhibitory Effect of Alkyl Isocyanates and Isothiocyanates on Mutagenesis in E. coli by Ultraviolet Radiation
- On the Relationship between C-13 Nuclear Magnetic Resonance Chemical Shift and Stability of Molecule in Methyl-Substituted N, N-Dimethylpiperidinium Salts
- Radical Methylation and Radical Hydroxymethylation of N-Substituted Quinoline Derivatives
- Studies on Hydrogen Exchange. XIV. Selective Hydrogen-Deuterium Exchange in Aliphatic Amines and Amino Acids catalyzed by Platinum
- Chemical Structure of QA_, One of the Covalently Bound Adducts of Carcinogenic 4-Nitroquinoline 1-Oxide with Nucleic Acid Bases of Cellular Nucleic Acids
- Studies on Chemical Alterations of Nucleic Acids and Their Components. X. syntheses and Reactivties of 3-Aminopyrimidine Nucleosides
- Selective Substitution Reactions of Quinoline Derivatives by Redox Systems Nucleophilic Character of Hydroxyalkyl Radicals
- 重水素標識化合物 (安定同位体の医・薬学,生物学への応用) -- (安定同位元素標識化合物)
- Studies on Chemical Alterations of Nucleic Acids and Their Components. VIII. Alkaline Rearrangement of 1-Aminoadenosine to 5-Amino-1-β-D-ribofuranosyl-4-(1,2,4-triazol-3-yl) imidazole
- Solvent-and Concentration-Dependent Shifts in Proton Magnetic Resonance of Quaternary Ammonium Salts
- Direct C-Amination of Guanosine with Hydroxylamine-O-Sulfonic Acid. Simplest Model Reaction possibly involved in DNA Damage leading to Carcinogenesis by N-Arylhydroxylamines
- Application of NMR to Stereochemistry. (I). The Spatial Interaction Effect of the Hydroxyl Group to Methyl Resonance.(53)
- 抗生物質の効果比較のための新しい手法と ED_ との相関性について
- Proton and Carbon-13 Nuclear Magnetic Resonance Chemical Shift Data for Nitroquinolines and Their N-Oxides
- Studies on Chemical Carcinogens and Mutagens. XXVI. Chemical Properties and Mutagenicity of Alkyl Alkanesulfonates on Salmonella typhimurium TA100
- Studies on Chemical Carcinogens and Mutagens. XXV. Chemoselectivity of Alkyl Sulfonates toward 4-(p-Nitrobenzyl) pyridine (NBP) in Phosphate Buffer
- Studies on Chemical Carcinogens and Mutagens. XXXII. Chemoselectivity of Alkylating Agents toward Pyridine in Aqueous Media-A Simple Procedure for Evaluation of Swain-Scott's Substrate Constants
- 学会誌のあり方について
- 薬学会賞受賞首藤紘一氏の業績
- 日本薬学会奨励賞受賞遠藤泰之氏の業績
- 薬剤師職能, 薬学教育を議論するために必要な認識
- 自然科学者としての一つの姿勢 : 良し悪しは別にして
- Lignified Materials as Potential Medicinal Resources.III. : Diversity of Biological Activity and Possible Molecular Species Involved
- 反応の律速因子の解明と制御(有機化学と生物の新しい接点を求めて)
- Studies on Chemical Carcinogens and Mutagens. XXXIII. : Mutation Frequencies Induced by Combinations of Methylating and/or Ethylating Mutagens
- 公開講座を語る
- Studies on Chemical Carcinogens. XXIII. A Simple Method for Characterization of the Alkylating Ability of Compounds by using 4-(p-Nitrobenzyl) pyridine
- Synthesis and Antitumor Effect of New Biological Alkylating Agents,Isethionic Acid Esters
- 学部教育では基礎学を, 薬剤師教育は修士課程で(薬学における有機化学教育のあり方)
- Alkaloids of Root-bark of Orixa japonica THUNB. XII. Nuclear Magnetic Resonance Study of N-Methylorixidinine, N-Methylisoorixidinine, and N-Methylorixidine.
- Studies on Chemical Carcinogens and Mutagens. XXXVI. : Apparent Activation Energy for Mutagenic Modification Induced in E. coli by Alkylating Agents. Estimation from Mutation Frequency
- Studies on Chemical Carcinogens and Mutagens. XXXV. : Standardization of Mutagenic Capacities of Several Common Alkylating Agents Based on the Concentration-Time Integrated Dose
- Application of Nuclear Magnetic Resonance to Stereochemistry. II. Determination of the Conformation of Hydroxyl Groups by Nuclear Magnetic Resonance ; Androst-4-en-3-one and Pregn-4-en-3-one Series.
- Effect of DL-α-Tocopherol (Vitamin E) on the Differentiation of Mouse Myeloid Leukemia Cell