Studies on Chemical Carcinogens. XXI. Quantitative Structure-Mutagenicity Relationship among Substituted Styrene Oxides

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概要

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• The quantitative structure-mutagenicity relationship among 8 substituted styrene oxides, p-methyl-, p-butyl, p-phenyl, p-chloro, m-chloro, p-cyano, p-nitro, and the parent styrene oxide, was examined. Mutagenic and cytocidal activities were correlated with the reactivity of the epoxide (Hammett's σ), the van der Waals volume of the molecule (V_W), and/or the partition parameter (π). Multiple regression analyses revealed that mutagenic capacity could be well described by a linear combination of σ and log V_W and that cytocidal capacity depended only on π of the derivatives, as already reported by Sugiura et al.

• 公益社団法人日本薬学会の論文
• 1982-04-25

著者

• 川添 豊

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 高橋 和彦

  横浜薬科大学

• 白井 直洋

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 高橋 和彦

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 川添 豊

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 高橋 和彦

  名市大 院

• 高橋 和彦

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 田村 信也

  Faculty of Pharmaceutical Sciences, Nagoya City University

• 白井 直洋

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 田村 信也

  Faculty Of Pharmaceutical Sciences Nagoya City University

• 高橋 和彦

  Faculty of Agriculture, Department of Horticulture, University of Tokyo

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