Singlet Oxygen Takes Part in 8-Hydroxydeoxyguanosine Formation in Deoxyribonucleic Acid Treated with the Horseradish Peroxidase-H_2O_2 System
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概要
- 論文の詳細を見る
Treatment of calf thymus deoxyribonucleic acid (DNA) with the horseradish peroxidase-H_2O_2 system resulted in effecient formation of 8-hydroxydeoxyguanosine (8-OH-dG) residues. It was concluded that singlet oxygen was the reactive species involved, based on experiments using active oxygen scavengers and D_2O. For 8-OH-dG formation, a higher-ordered polynucleotide structure seems to be required : double stranded DNA was a better substrate for the reactive species than single stranded DNA, and monomeric deoxyguanosine underwent C8-hydroxylation to a lesser extent.
- 社団法人日本薬学会の論文
- 1990-11-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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幸田 光復
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
名古屋市立大学薬学部
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幸田 光復
Faculty Of Pharmaceutical Sciences Nagoya City University
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中川 隆
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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中川 隆
名古屋市立大学 救急部
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中川 隆
Faculty Of Pharmaceutical Sciences Nagoya City University
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