Formation of O^6,7-Dimethylguanine Residues in Calf Thymus Deoxyribonucleic Acid Treated with Carcinogenic N-Methyl-N-nitrosourea in Vitro
スポンサーリンク
概要
- 論文の詳細を見る
Treatment of calf thymus deoxyribonucleic acid (DNA) in vitro with a methylating carcinogen, N-methyl-N-nitrosourea (MNU), in phosphate buffer (pH 7.2) resulted in formation of O^6,7-dimethylguanine residues in DNA besides the well-known methylated DNA adducts, 7-methylguanine, O^6-methylguanine and 3-methyladenine. The product ratio (%) of O^6,7-dimethylguanine versus 7-methylguanine was 0.32 after one MNU treatment. The significance of formation of O^6,7-dimethylguanine residues in DNA is discussed briegly in relation to the carcinogenicity of MNU.
- 社団法人日本薬学会の論文
- 1991-03-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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幸田 光復
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
名古屋市立大学薬学部
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幸田 光復
Faculty Of Pharmaceutical Sciences Nagoya City University
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沢田 典昭
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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沢田 典昭
Faculty Of Pharmaceutical Sciences Nagoya City University
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