Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N',N'-dimethyl-N-nitrosourea(Biological)
スポンサーリンク
概要
- 論文の詳細を見る
N-Butyl-N',N'-dimethyl-N-nitrosourea (DM-BNU), the spontaneous (hydrolytic) activation rate of which is 4×10^<-4> times that of N-butyl-N-nitrosourea (BNU), is metabolized to N-butyl-N'-methyl-N-nitrosourea (MM-BNU) in the presence of S9 mix. It is, therefore, suggested that the carcinogenicity of DM-BNU, which is as potent as that of BNU, may be attributed partly to the demethylated MM-BNU, which is more readily activated to a carcinogenic reactant. This hypothesis is supported by the mutagenicilies of these carcinogens in E. coli in the presence and absence of S9 mix.
- 社団法人日本薬学会の論文
- 1986-12-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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二宮 眞一
Faculty of Pharmaceutical Scienes, Nagoya City University
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幸田 光復
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
名古屋市立大学薬学部
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幸田 光復
Faculty Of Pharmaceutical Sciences Nagoya City University
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羽倉 昌志
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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羽倉 昌志
Faculty Of Pharmaceutical Sciences Nagoya City University
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二宮 真一
Tokai Research Laboratories Daiichi Pure Chemicals Co. Ltd.
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二宮 眞一
Faculty Of Pharmaceutical Scienes Nagoya City University
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