Metabolism of Mutagenicity-Deprived 3-Fluoroquinoline : Comparison with Mutagenic Quinoline
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概要
- 論文の詳細を見る
3-Fluorinated quinoline (3FQ), a non-mutagenic derivative of the potent mutagen quinoline, was metabolized with a microsomal enzyme fraction isolated from the 3-methylcholanthrene-treated rat liver. The metabolites were 3-fluoro-5,6-dihydroquinoline-5,6-trans-diol (72%), 3-fluoroquinoline 1-oxide (6%), 3-fluoro-5,6-dihydroquinoline-5,6-cis-epoxide (1%), and 4 unidentified metabolites (11%). Since this metabolic pattern is similar to that obtained with unfluorinated quinoline, the epoxidation of the benzene moieties of quinoline and 3-fluoroquinoline is most likely a detoxication process and not mutagenic activation.
- 公益社団法人日本薬学会の論文
- 1993-03-15
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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高橋 和彦
横浜薬科大学
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高橋 和彦
Faculty of Pharmaceutical Sciences, Nagoya City University
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佐伯 憲一
Faculty Of Pharmaceutical Sciences Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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高橋 和彦
名市大 院
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高橋 和彦
Faculty Of Pharmaceutical Sciences Nagoya City University
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高橋 和彦
Faculty of Agriculture, Department of Horticulture, University of Tokyo
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