DEPRIVATION OF THE MUTAGENIC PROPERTY OF QUINOLINE : INHIBITION OF MUTAGENIC METABOLISM BY FLUORINE SUBSTITUTION
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概要
- 論文の詳細を見る
3-Fluoro-, 2- and 3-chloro-quinolines were deficient in mutagenicity in S__-. <typhimurium>___- TA100,whereas all the other fluoro and chloro derivatives examined were mutagenic. Together with mutagenic property of methylquinolines, the mutagenic metabolite of quinoline is presumed to be the 2,3-dihydro-2,3-epoxide of 1,4-hydrate form of quinoline. A possibility is proposed that a fluorine substitution may deprive the aromatic compounds of the genotoxicity.
- 社団法人日本薬学会の論文
- 1988-11-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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高橋 和彦
横浜薬科大学
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幸田 光復
Faculty of Pharmaceutical Sciences, Nagoya City University
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幸田 光復
Faculty Of Pharmaceutical Sciences Nagoya City University
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高橋 和彦
Faculty of Pharmaceutical Sciences, Nagoya City University
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神谷 正嗣
Faculty of Pharmaceutical Sciences, Nagoya City University
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仙石 葉子
Faculty of Pharmaceutical Sciences, Nagoya City University
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仙石 葉子
Faculty Of Pharmaceutical Sciences Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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高橋 和彦
名市大 院
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高橋 和彦
Faculty Of Pharmaceutical Sciences Nagoya City University
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神谷 正嗣
Faculty Of Pharmaceutical Sciences Nagoya City University
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高橋 和彦
Faculty of Agriculture, Department of Horticulture, University of Tokyo
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