Studies on Chemical Carcinogens and Mutagens. XXXIII. : Mutation Frequencies Induced by Combinations of Methylating and/or Ethylating Mutagens
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概要
- 論文の詳細を見る
In order to study the mutagenic interaction between two chemicals, the mutation frequencies induced by simultaneous (combined) treatments of Salmonella typhimurium TA100 with two simple alkylating agents were compared with those induced by separate treatments with the two mutagens. The results indicated that etthylations produced by two ethylating agents, N-ethyl-N-nitrosourea (ENU) and ethyl methanesulfonate (EMS) may be recognized as equivalent mutational damage of deoxyribonucleic acid (DNA) by the host cell tested, and that methylation by N-methyl-N-nitrosourea and ethylation by either ENU or EMS may be recognized as partially but not entirely equivalent damage of DNA leading to mutation. In contrast, the isopropylation by N-isopropyl-N-nitrosourea appeared to be independent of either methylation or ethylation in inducing mutation. An analytical method for the classification of the mutagenic interactions as "equivalent" or "independent, " is proposed.
- 公益社団法人日本薬学会の論文
- 1986-01-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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幸田 光復
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
名古屋市立大学薬学部
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幸田 光復
Faculty Of Pharmaceutical Sciences Nagoya City University
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羽倉 昌志
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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羽倉 昌志
Faculty Of Pharmaceutical Sciences Nagoya City University
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