Effect of Metal Ions on Transcription of the ada Gene Which Encodes O^6-Methylguanine-DNA Methyltransferase of Escherichia coli
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概要
- 論文の詳細を見る
The effect of metal ions on transcription of the ada gene of Escherichia coli which is promoted by Ada protein in the presence of methylated deoxyribonucleic acid (DNA) was examined in a reconstituted system. Their effect on the O^6-methylguanine-DNA methyltransferase (MGTase) activity of Ada protein was also examined. Ag^+, Cd^<2+>, Cu^<2+> and Hg^<2+> severely inhibited transcription of the ada gene at a dose which inhibited neither transcription of the lacUV5 gene nor MGTase activity. Zn^<2+> inhibited both transcription and MGTase activity in the same does range. Al^<3+> and Fe^<3+> inhibited transcription of both ada and lacUV5 genes without affecting the MGTase activity of Ada protein.
- 公益社団法人日本薬学会の論文
- 1992-09-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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高橋 和彦
横浜薬科大学
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高橋 和彦
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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高橋 和彦
名市大 院
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高橋 和彦
Faculty Of Pharmaceutical Sciences Nagoya City University
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鈴木 任
Faculty of Pharmaceutical Sciences, Nagoya City University
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関口 睦夫
Department of Biochemistry, Faculty of Medicine, kyushu University
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関口 睦夫
Department Of Biochemistry Faculty Of Medicine Kyushu University
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鈴木 任
Faculty Of Pharmaceutical Sciences Nagoya City University
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高橋 和彦
Faculty of Agriculture, Department of Horticulture, University of Tokyo
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