Deoxyribonucleic Acid (DNA) Damage Induced by Bleomycin-Fe(II) in Vitro : Formation of 8-Hydroxyguanine Residues in DNA
スポンサーリンク
概要
- 論文の詳細を見る
Treatment of calf thymus deoxyribonucleic acid (DNA) with bleomycin-Fe(II) at 0℃ for 5 min resulted in the formation of 8-hydroxyguanine (8-OH-Gua) residues in DNA in a dose dependent manner, in addition to the formation of base propenal, a DNA-degradation product. The amount of 8-OH-Gua was about one-hundredth of that of base propenal. Treatment of cellular DNA with bleomycin did not result in any increase of 8-OH-Gus even under conditions of 100% cell killing.
- 社団法人日本薬学会の論文
- 1989-04-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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幸田 光復
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
名古屋市立大学薬学部
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幸田 光復
Faculty Of Pharmaceutical Sciences Nagoya City University
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葛西 宏
Biology Division, National Cancer Center Research Institute
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小川 隆博
Faculty of Pharmaceutical Sciences, Nagoya City University
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鈴木 考昌
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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葛西 宏
Biology Division National Cancer Center Research Institute
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小川 隆博
Faculty Of Pharmaceutical Sciences Nagoya City University
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鈴木 考昌
Faculty Of Pharmaceutical Sciences Nagoya City University
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