Radical Methylation and Radical Hydroxymethylation of N-Substituted Quinoline Derivatives
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概要
- 論文の詳細を見る
N-substituted quinoline derivatives such as 〓N^+-Me, 〓N^+O^-, 〓N^+-NH^- were derived to methyl substituted compound at C-2 and/or C-4 by radical methylation and by radical hydroxymethylation. In the case of radical methylation and radical hydroxymethylation of quinoline 1-oxides, carbon at C-2 was preferentially nucleophilic than at C-4. Useful way to synthesize the alkyl substituted derivatives at C-2 selectively was to proceed the alkylation after forming N-oxide.
- 公益社団法人日本薬学会の論文
- 1978-04-25
著者
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川添 豊
Faculty of Pharmaceutical Sciences, Nagoya City University
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川添 豊
Faculty Of Pharmaceutical Sciences Nagoya City University
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糸川 秀治
東京薬科大学 薬学部
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前田 満和
National Cancer Center Research Institute
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春田 龍二
Tokyo College of Pharmacy
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川添 豊
Nagoya City University
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田崎 敏夫
東京薬科大学
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