Isolation and Antitumor Activity of Cyclic Hexapeptides Isolated from Rubiae Radix
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概要
- 論文の詳細を見る
The details of the isolation and antitumor activity of cyclic hexapeptides (RA-VII, RA-V, RA-IV and RA-III) isolated from Rubia cordifolia are reported. Studies on a spectrum of experimental tumors in mice revealed that the peptides exhibited significant activity against leukemias and ascites tumors, P-388,L1210,B-16 melanoma and solid tumors, colon 38,Lewis lung carcinoma and Ehrlich carcinoma. RA-V had an especially potent effect on MM2 mammary carcinoma in mice. The effective dose range of RA-IV against P-388 leukemia was different from those of the other cyclic hexapeptides.
- 社団法人日本薬学会の論文
- 1984-01-25
著者
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糸川 秀治
東京薬科大学 薬学部
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薗部 徹
Tobishi Pharmaceutical Co. Ltd.
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竹谷 孝一
Tokyo College of Pharmacy
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森 登
Tobishi Pharmaceutical Co.,Ltd.
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浜中 敏議
Tobishi Pharmaceutical Co.,Ltd.
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森 登
Tokyo College of Pharmacy
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浜中 敏議
Tokyo College of Pharmacy
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薗部 徹
Tokyo College of Pharmacy
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三原 和彦
Tokyo College of Pharmacy
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三原 和彦
東京薬大
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森 登
Tobishi Pharmaceutical Co. Ltd.
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森 登
東菱薬品工業小金井研
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浜中 敏議
Tobishi Pharmaceutical Co. Ltd.
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